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Evidence-Based Policy Making in Nepal: Challenges and the Way Forward

“Life and health can never be exchanged for other benefits within the society.” With this vision, the Swedish Parliament in 1997 adopted Vision Zero, a road traffic safety project that aims to minimize serious injuries and fatalities surrounding road traffic accidents. Vision Zero revisioned the concept of road users as the ultimate responsibility bearers but rather the responsibility is shared by transportation system designers and road users. ....

Federal Democratic Republic Of Nepal , Central Bureau Of Statistics , National Population , Tribhuvan University , National Statistics Office , University Grant Commission , Nepal Labor Force , Research Development , National Economic Census , Nepal Multiple Indicator Cluster , Swedish Parliament , Nepal Living Standards , Business Incubation Centers , Vision Zero , Based Policy Making , Federal Democratic Republic , Central Bureau , Housing Census , Agriculture Census , Nepal Living Standards Survey , Nepal Labor Force Survey , Nepal Multiple Indicator Cluster Survey , Services Survey , Oad Traffic Safety Project , Evidence Based Policymaking , Hallenges In Nepal ,

Frontiers | Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases

The majority of genetic variants for psychiatric disorders have been found within non-coding genomic regions. Physical interactions of gene promoters with distant regulatory elements carrying risk alleles may explain how the latter affect gene expression. Recently, whole genome maps of long-range chromosomal contacts from human postmortem brains have been integrated with gene sequence and chromatin accessibility data to decipher disease-specific alterations in chromatin architecture. Cell culture and rodent models provide a causal link between chromatin conformation, long-range chromosomal contacts, gene expression, and disease phenotype. Here, we give an overview of the techniques used to study chromatin contacts and their limitations in brain research. We present evidence for three-dimensional genome changes in physiological brain function and assess how its disturbance contributes to psychiatric disorders. Lastly, we discuss remaining questions and future research directions with a ....

New York , United States , Ali Javaid , Snps Mitchell , Schahram Akbarian Mount , Interdisciplinary Center , Common Mind Consortium , Psychiatric Genomics Consortium , Available Datasets , Epigenomics Project , Genomics Consortium , Mind Consortium , Schizophrenia Spectrum , Chromatin Interactomes , Paired Immunoglobin Like Type , Regulatory Element Binding Transcription Factor , Greek Learning , Bifurcated Histone Lysine Methyltransferase , Myocyte Enhancer Factor , Medical Research , Schahram Akbarian , Mount Sinai Hospital , Med Abstract , Crossref Full Text , Sci United , Chromatin Architecture ,