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Errant DNA boosts immunotherapy effectiveness


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IMAGE: A UT Southwestern study discovered the molecular mechanism by which tumors defective in DNA mismatch repair respond to immunotherapy. This illustration depicts how cells use a programmed mismatch repair deficiency-activated.
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Credit: Illustration by Yipin Wu
DALLAS - Dec. 17, 2020 - DNA that ends up where it doesn t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in
Cancer Cell, suggest that delivering radiation - which triggers DNA release from cells - before immunotherapy could be an effective way to fight cancers that are challenging to treat. ....

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Bloomber Businessweek: The Essex Boys: How Nine Traders Hit a Gusher With Negative Oil


ILLUSTRATION: SOPHY HOLLINGTON FOR BLOOMBERG BUSINESSWEEK
By Liam Vaughan, Kit Chellel, and Benjamin BainDecember 10, 2020, 12:01 AM EST
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Among the many previously unthinkable moments of 2020, one of the strangest occurred on April 20, when the price of crude oil fell below zero. West Texas Intermediate futures, the most popular instrument used to trade the commodity, had started the day at $18 a barrel. That was already low, but prices kept tumbling until, at 2:08 p.m. New York time, they went negative.
Amazingly, that meant anyone selling oil had to pay someone else to take it off their hands. Then the crude market collapsed completely, falling almost $40 in 20 minutes, to close at –$38. It was the lowest price for oil in the 138-year history of the New York Mercantile Exchange and in all likelihood the lowest price in the millennia since humans first began burning the stuff for heat and light. ....

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