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Research shows that human immune system uses ancient family of cell death proteins also found in bacteria

The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to defend them ....

United States , Brianna Duncan Lowey , Yaara Oppenheimer Shaanan , Gil Amitai , Erez Yimiya , Tanita Wein , Alex Johnson , Philip Kranzusch , Rotem Sorek , Megan Mayer , Burroughs Wellcome Fund , Weizmann Institute Of Science , Barry Sherman Institute For Medicinal Chemistry , Weizmann Institute , Life Science Research Foundation , Weizmann Institute Sustainability , Bonnie Beutler Research Program Of Excellence , Dana Farber Cancer Institute , Parker Institute For Cancer Immunotherapy , Harvard Center , Herchel Smith Graduate Research Fellowship , Pew Biomedical Scholars Program , Energy Research Initiative , German Ministry For Education , Israel Science Foundation , Knell Family Center ,

Research reveals that human immune system uses ancient family of cell death proteins also in bacteria

The human immune system, that marvel of complexity, subtlety, and sophistication, includes a billion-year-old family of proteins used by bacteria to ....

United States , Brianna Duncan Lowey , Yaara Oppenheimer Shaanan , Gil Amitai , Erez Yimiya , Tanita Wein , Alex Johnson , Philip Kranzusch , Rotem Sorek , Megan Mayer , Burroughs Wellcome Fund , Weizmann Institute Of Science , Barry Sherman Institute For Medicinal Chemistry , Weizmann Institute , Life Science Research Foundation , Weizmann Institute Sustainability , Bonnie Beutler Research Program Of Excellence , Dana Farber Cancer Institute , Parker Institute For Cancer Immunotherapy , Harvard Center , Herchel Smith Graduate Research Fellowship , Pew Biomedical Scholars Program , Energy Research Initiative , German Ministry For Education , Israel Science Foundation , Knell Family Center ,

Advanced mouse embryos grown outside the uterus

E-Mail
To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years. Prof. Jacob Hanna of the Weizmann Institute of Science and his group have now accomplished this feat. The method they created for growing mouse embryos outside the womb during the initial stages after embryo implantation will give researchers an unprecedented tool for understanding the development program encoded in the genes, and it may provide detailed insight into birth and developmental defects as well as those involved in embryo implantation. The results of this research were published in ....

Chen Itzkovich , Valeriya Chugaeva , Ilana Mantoux , Itay Maza , Alejandro Aguilera Castrejon , Mirie Zerbib , Rada Massarwa , Jonathan Bayerl , Saifeng Cheng , Jacob Hanna , Muneef Ayyash , Shadi Tarazi , Tom Shani , Zvia Zeroni , Hadas Keren Shaul , Raanan Shlomo , Shahd Ashouokhi , Lior Lasman , Daoud Sheban , Yoseph Addadi , Noa Novershtern , Yonatan Stelzer , Bernardo Oldak , Nir Livnat , Sergey Viukov , Israel Cancer Research Fund ,

Evolved to stop bacteria, designed for stability

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Connections are crucial. Bacteria may be most dangerous when they connect - banding together to build fortress-like structures known as biofilms that afford them resistance to antibiotics. But a biomolecular scientist in Israel and a microbiologist in California have forged their own connections that could lead to new protocols for laying siege to biofilm-protected colonies. Their research was published in the
Proceedings of the National Academy of Sciences (
PNAS), USA.
This interdisciplinary collaboration began with a lecture given at the Weizmann Institute of Science in the Life Sciences Colloquium. Prof. Dianne Newman of the California Institute of Technology was the speaker, and the Institute s Prof. Sarel Fleishman, of the Biomolecular Sciences Department, decided to attend, even though the lecture had no immediately apparent bearing on his own research. Newman described an enzyme she had discovered that could interrupt the metabolism of the biofi ....

United States , California Institute Of Technology , Olga Khersonsky , Sam Switzer , Carolyn Hewitt , Chelseym Vandrisse , Anne Christopoulos , Sarel Fleishman , Rosalie Lipsh Sokolik , Dianne Newman , Sarel Jacob Fleishman , Irving Kipnes Foundation , Joycee Eisenberg Foundation , Weizmann Institute Of Science , Life Sciences Colloquium , Barry Sherman Institute For Medicinal Chemistry , Proceedings Of The National Academy Sciences , Biomolecular Sciences Department , Institute Prof , Milner Foundation , Schwartz Reisman Collaborative Science Program , Sela Center , Sam Ousher Switzer Charitable Foundation , National Academy , Weizmann Institute , Life Sciences ,

Stress Response Protein Links Inflammatory Disease to Colon Cancer

Weizmann Institute of Science
The findings might help identify those at extra risk of this cancer and develop means of prevention
Inflammation promotes some of the deadliest cancers. In the colon, inflammatory bowel disease is well known to be associated with higher-than-average rates of malignancy. Nevertheless, the developing tumor is commonly diagnosed only when it has already advanced or even metastasized, possibly because the early symptoms of malignancy are often mistakenly ascribed to a flare-up of intestinal inflammation. Weizmann Institute of Science researchers have now revealed a molecular missing link between chronic gut inflammation and cancer. This revelation may help develop ways of preventing colon cancers in people with inflammatory diseases of the intestines. ....

New York , United States , Memorial Sloan Kettering Cancer Center , City Of , United Kingdom , Shimrit Mayer , Liorh Katz , Gil Friedman , Reinat Nevo , Ido Laish , Hagar Lavon , Ruth Scherz Shouval , Aliza Yemini , David Kelsen , Johna Porco , Ofra Golani , Rina Wassermann Dozorets , Rona Yaeger , Laurene Brown , Yaniv Stein , Drors Shouval , Erik Sahai , Esther Wershof , Wenhan Zhang , Meirav Pevsner Fischer , Oshrat Levi Galibov ,