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An international study led by the medical Faculty of the University of Bonn has identified a gene that plays an important role in the development of the human embryo. If it is altered, malformations of various organ systems can result.
The zebrafish is utilized by scientists all over the world as a model organism because it may be used to investigate crucial physiological processes that occur similarly in the human body.
E-Mail IMAGE: Fluorescence image of two zebrafish embryos - After switching off the Plexin-A1 gene (bottom), malformations of the nervous system occur, such as a pathological enlargement of the neural fluid spaces... view more Credit: Dr. Gabriel Dworschak / University of Bonn When the Augustinian monk Gregor Mendel crossed white-flowering with purple-flowering pea plants in the mid-19th century, he made an interesting discovery: The offspring were all purple. He therefore called this trait dominant, while the white blossom color was recessive. The reason for this phenomenon: In p...
Plexin-A1 gene plays a more extensive role in brain development, study shows Study by the University of Bonn shows that mutations of the investigated gene manifest in different patterns of inheritance. The so-called Plexin-A1 gene seems to play a more extensive role in brain development than previously assumed. This is shown by a current study led by the University Hospital Bonn and the Institute of Anatomy of the University of Bonn with more than 60 international partners. The gene is also interesting for another reason: Its mutations are inherited either dominantly or recessively, depending...