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How do mutations benefit SARS-CoV-2? To explore this, a team of researchers from China took a closer look at the physical interactions that occur between the proteins after viral mutation.
Llama-derived nanobodies show neutralizing activity against SARS-CoV-2 variants of concern in vitro With the emergence of new variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic, the prospect of effective containment of viral transmission has receded. Not only are they more transmissible than the earlier strains, but they also offer partial resistance to neutralization by existing antibodies in some cases. Moreover, they can evade detection by current antigen detection kits because of mutations ...
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Researchers in France report impaired neutralization of two new SARS-CoV-2 variants by antibodies induced by vaccination or natural infection.
Researchers describe the impending rise to dominance of the B.1.1.7 (UK) variant in the US. Understanding this development will help to shape preventive action to reduce the infection and mortality rates.
A new preprint research paper posted to the bioRxiv server reports the development of highly effective neutralizing nanobodies targeting the viral receptor-binding domain (RBD), thus disrupting its engagement with the host cell angiotensin-converting enzyme 2 (ACE2) receptor.