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AAAS 2024: Chemo brain, other conditions provide lens for long COVID

The biological processes giving rise to the central nervous system symptoms of long COVID remain a mystery. But multiple studies suggest they do not appear to be a result of a direct viral infection of brain tissue. The latest such research, which appeared online in Nature Neuroscience on Feb. 16, 2024, demonstrated that local immune response in brain tissues persisted long after SARS-CoV-2 virus had disappeared. ....

Nature Neuroscience , Bioworld Science , Long Covid , Sars Cov 2 , Post Covid Syndrome , Aaas 2024 , Neurology Psychiatric ,

Multivalent mRNA vaccine prevents mpox disease

A vaccine based on messenger RNA (mRNA) technology against four surface proteins of the envelope and the inner membrane of the mpox virus (MPXV) demonstrated its efficacy in two animal models. Biontech SE scientists designed and tested two different combinations of antigens in mice and macaques for the two infective forms of the virus. One of them showed better results for its evaluation in clinical trials preventing the disease. ....

Bioworld Science , Mpox Vaccines , Orthopox Viruses , Biontech Se , Drug Design , Rug Delivery And Technologies ,

Gene-by-gene approach, diverse sample yields new AD risk genes

Investigators at the National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) have used a gene-constrained analysis to identify nine new Alzheimer’s disease (AD) risk genes that are possibly linked to the higher prevalence of AD in people with African ancestry. One of those genes, GNB5, regulates the stability of certain G protein-signaling proteins, which are activated by G protein-coupled receptors (GPCRs). The authors showed that mice with only one copy of Gnb5 developed more amyloid plaques and tau tangles than those with two copies. ....

National Institute Of Diabetes , National Institute , Kidney Disorders , Bioworld Science , Neurology Psychiatric , Alzheimers Disease , G Protein Coupled Receptors ,

Degrading damaged mitochondria improves concussion

In repeated concussions, removing damaged mitochondria could prevent the neurodegeneration that occurs when pathology progresses in some patients. The key would be in the role of the p17 protein in restoring mitophagy, according to scientists from the Medical University of South Carolina (MUSC). ....

University Of South Carolina , Medical University , South Carolina , Bioworld Science , Brain Injury , Medical University Of South Carolina , Neurology Psychiatric , Drug Design , Rug Delivery And Technologies ,

Newco news: Vision Care's iPS retinal cells primed for global market

Vision Care Group CEO Masayo Takahashi led the world s first clinical study of a retinal cell transplant derived from induced pluripotent stem cells (iPS cells) in 2014 when she led the Laboratory for Retinal Regeneration at Japan’s Riken Center for Biosystems Dynamics Research. In 2019, she founded Vision Care and subsequently founded two subsidiary companies dedicated to developing cell and gene therapies. ....

Masayo Takahashi , Vision Care Group , Biosystems Dynamics Research , Retinal Regeneration , Riken Center , Biosystems Dynamics , Vision Care , Age Related Macular Degeneration , Retinitis Pigmentosa , Retinal Pigment Epithelial Cells , Bioworld Science , Newco News , Asia Pacific ,