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Six-hour time-restricted feeding inhibits lung cancer progression and reshapes circadian metabolism | BMC Medicine

Accumulating evidence has suggested an oncogenic effect of diurnal disruption on cancer progression. To test whether targeting circadian rhythm by dietary strategy suppressed lung cancer progression, we adopted 6-h time-restricted feeding (TRF) paradigm to elucidate whether and how TRF impacts lung cancer progression. This study used multiple lung cancer cell lines, two xenograft mouse models, and a chemical-treated mouse lung cancer model. Stable TIM-knockdown and TIM-overexpressing A549 cells were constructed. Cancer behaviors in vitro were determined by colony formation, EdU proliferation, wound healing, transwell migration, flow cytometer, and CCK8 assays. Immunofluorescence, pathology examinations, and targeted metabolomics were also used in tumor cells and tissues. mCherry-GFP-LC3 plasmid was used to detect autophagic flux. We found for the first time that compared to normal ad libitum feeding, 6-h TRF inhibited lung cancer progression and reprogrammed the rhythms of metabolites ....

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ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

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Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration. ....

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New study proves that chlorine dioxide (MMS) blocks SARS-CoV-2 spike proteins from binding with human receptors

New study proves that chlorine dioxide (MMS) blocks SARS-CoV-2 spike proteins from binding with human receptors
naturalnews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from naturalnews.com Daily Mail and Mail on Sunday newspapers.

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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

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