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Electromagnetic lensing using the Aharonov–Bohm effect

Electromagnetic lensing using the Aharonov–Bohm effect
iop.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from iop.org Daily Mail and Mail on Sunday newspapers.

Martin Linck , Professor Rafael Ayala University Of Seville , Electron Microscopy Sciences , Life Science Research , Professor Dmitry Feichtner Kozlov University Of Bremen , Professor Takuya Mine Kyoto Institute Of Technology , Professor Takuya Mine , Kyoto Institute , Professor Dmitry Feichtner Kozlov , Professor Rafael Ayala , Kakenhi Grant In Aid , Platform Project , Supporting Drug Discovery , Grant Number , Kawasaki Science , Thermo Fisher Scientific , Gatan Quantum , Magnitude Sorted List , Multi Clustering Phase Unwrapping Algorithm ,

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex ....

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Vibrating Slicer Market Analysis and Future Prospects for 2030

Vibrating Slicer Market Analysis and Future Prospects for 2030 ....

United States , Parmeet Singh , Asia Pacific , Leica Biosystems , Dhirtek Business Research , Electron Microscopy Sciences , Harvard Apparatus , Sample Report , Comprehensive Analysis , Path Forward , Strategic Implications , Competitive Landscape , Vibrating Slicer , Amos Scientific , Campden Instruments , Harvard Apparatus Limited , Lafayette Instrument , World Precision Instruments , Semi Automatic , Fully Automatic , Medical College , Regional Dynamics , North America , Latin America , Middle East , Business Research ,

Neural landscape diffusion resolves conflicts between needs across time

Animals perform flexible goal-directed behaviours to satisfy their basic physiological needs1–12. However, little is known about how unitary behaviours are chosen under conflicting needs. Here we reveal principles by which the brain resolves such conflicts between needs across time. We developed an experimental paradigm in which a hungry and thirsty mouse is given free choices between equidistant food and water. We found that mice collect need-appropriate rewards by structuring their choices into persistent bouts with stochastic transitions. High-density electrophysiological recordings during this behaviour revealed distributed single neuron and neuronal population correlates of a persistent internal goal state guiding future choices of the mouse. We captured these phenomena with a mathematical model describing a global need state that noisily diffuses across a shifting energy landscape. Model simulations successfully predicted behavioural and neural data, including population ne ....

Atlas Ccfv , Ngai Rxfp , Tprime Karsh , Jupyter Ipython , Allen Brain Institute , Electron Microscopy Sciences , Allen Institute Ccfv , Allen Institute Brain Atlas , Thermo Fisher , National Institutes Of Health , Allen Institute Mouse Brain Atlas , Stanford University , Administrative Panel , Laboratory Animal Care , National Institutes , World Precision Instruments , Jam Systems , Basler Ace , Bpod Generation , Extended Data , Harvard Apparatus , Multi Probe Manipulator , New Scale Technologies , Texas Instruments , Allen Brain Atlas , Allen Institute ,

IL-31–dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis

IL-31–dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis
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Celltrace Violet , Fortessa Becton Dickinson , Cytometry Colab , Stallergenes Greer , Zeiss Axioimager , Corning Biocoat , Library Kit , Labchart Pro Software , Beckman Coulter , Harwell Institute , Electron Microscopy Sciences , Institute For Human Genetics , Sandler Foundation , Biostir Inc , Dermatology Foundation Career Development Award , European Mutant Mouse Archive , Trace Violet , Thermo Fisher Scientific , Flowjo Proliferation Platform , Omega Scientific , Becton Dickinson , Alexa Fluor , Molecular Devices , Fibrous Tissue Kit , Micro Kit , Invitrogen Superscript ,