Live Breaking News & Updates on Lipofectamine rnai

Stay informed with the latest breaking news from Lipofectamine rnai on our comprehensive webpage. Get up-to-the-minute updates on local events, politics, business, entertainment, and more. Our dedicated team of journalists delivers timely and reliable news, ensuring you're always in the know. Discover firsthand accounts, expert analysis, and exclusive interviews, all in one convenient destination. Don't miss a beat — visit our webpage for real-time breaking news in Lipofectamine rnai and stay connected to the pulse of your community

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex with SPSB3 reveals a highly conserved Asn-Asn (NN) minimal degron motif at the C terminus of cGAS that directs SPSB3 recruitment, ubiquitylation and cGAS protein stability. Interference with SPSB3-regulated nuclear cGAS degradation primes cells for type I interferon signalling, conferring heightened protection against infection by DNA viruses. Our research defines protein degradation as a determinant of cGAS regulation in the nucleus and provides structural insights into an element of cGAS that is amenable to therapeutic exploitation. The ubiquitin proteasomal system degrades nuclear cGAS in cycling cells.

Fiji , Coomassie , Ashanti , Ghana , Cytiva-akt , Lipofectamine-rnai , Jackson-immunoresearch , Microplates-perkin-elmer , Q-exactive-orbitrap , Phenoplate-perkinelmer , Perkinelmer , Proteome-software

Association of an estrogen-sensitive Pax1-Col11a1-Mmp3 signaling axis with adolescent idiopathic scoliosis

Association of an estrogen-sensitive Pax1-Col11a1-Mmp3 signaling axis with adolescent idiopathic scoliosis
elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.

Hong-kong , Cambridge , Cambridgeshire , United-kingdom , Niigata , Japan , Indiana , United-states , Shriners-hospital-for-children , Kentucky , Tokyo , Massachusetts

The injury response to DNA damage in live tumor cells promotes antitumor immunity

The injury response to DNA damage in live tumor cells promotes antitumor immunity
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United-states , American , Tocris-biosciences , Taconic-biosciences , Lipofectamine-rnai , P-steinberger-addgene , Babette-tang , Antifade-mountant-invitrogen , Marble-center , Broad-institute , Cellular-technology-limited-immunospot , Environmental-health

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United-states , American , Lipofectamine-rnai , Lipofectamine-rnaimax-invitrogen , Electron-microscopy-sciences , Mattek-corporation , Gg-kit-cell-signaling-technology , Jackson-laboratory , Wistar-institute , Like-parkin , American-type-culture-collection , Protease-inhibitor-cocktail

Osteoclasts and Glucose Uptake-Related Insulin Resistance

Osteoclasts and Glucose Uptake-Related Insulin Resistance
dovepress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dovepress.com Daily Mail and Mail on Sunday newspapers.

United-states , China , Shanghai , Gongli , Zhejiang , Resistin-quantikine , Lipofectamine-rnai , Ibm , National-collection-of-authenticated-cell-cultures-shanghai , Animal-care-committee-of-shanghai-gongli-hospital , Tiangen-biotech-co , Animals-national-research-council

The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit

The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

Miami , Florida , United-states , China , Shanghai , Huashan , Henan , Chinese , Lipofectamine-rnai , Cyagen-company-shanghai , Fudan-university-shanghai-medical-college