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ABT, DHR, DXCM: Which "Strong Buy" Healthcare Stock Has More Upside?

ABT, DHR, DXCM: Which "Strong Buy" Healthcare Stock Has More Upside?
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Abbott-labs , Ge-healthcare-life-sciences , Freestyle-libre , Price-target , Strong-buy , Life-sciences , Capital-markets ,

3D Bio Printing Market Size Worth $5.2 billion By 2032: IndustryARC

3D Bio Printing Market Size Worth $5.2 billion By 2032: IndustryARC
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Italy , Indonesia , China , Germany , Belgium , Brazil , Malaysia , Netherlands , United-states , Russia , Ukraine , India

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex with SPSB3 reveals a highly conserved Asn-Asn (NN) minimal degron motif at the C terminus of cGAS that directs SPSB3 recruitment, ubiquitylation and cGAS protein stability. Interference with SPSB3-regulated nuclear cGAS degradation primes cells for type I interferon signalling, conferring heightened protection against infection by DNA viruses. Our research defines protein degradation as a determinant of cGAS regulation in the nucleus and provides structural insights into an element of cGAS that is amenable to therapeutic exploitation. The ubiquitin proteasomal system degrades nuclear cGAS in cycling cells.

Fiji , Coomassie , Ashanti , Ghana , Cytiva-akt , Lipofectamine-rnai , Jackson-immunoresearch , Microplates-perkin-elmer , Q-exactive-orbitrap , Phenoplate-perkinelmer , Perkinelmer , Proteome-software

Edity Therapeutics Announces Appointment of Abigail Bracha, PhD as President

Edity Therapeutics Announces Appointment of Abigail Bracha, PhD as President
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Israel , Rehovot , Hamerkaz , Abigail-bracha , Michal-golan-mashiach , Amazon-web-services , Harvard-university-in-experimental-pathology , Ge-healthcare-life-sciences , Business-development , National-science-foundation-graduate-research , Edity-therapeutics-announces-appointment , New-president

SmartLabs Announces Biopharma Veteran Brian Taylor as New Interim CEO

SmartLabs Announces Biopharma Veteran Brian Taylor as New Interim CEO
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Boston , Massachusetts , United-states , Brian-taylor , Clayton-freeman , Its-managed-research-centers , Our-universal-lab-framework , Ge-healthcare-life-sciences , Smartlabs-inc , Biomanufacturing-solutions , Biopharma-solutions , Chief-executive-officer

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent

mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent
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Guinea , Kyoto , Japan , Canada , Powassan , Ontario , United-states , America , Supermix-bio-rad , Qiagen-rneasy , Cleancap-trilink , Mann-whitney-welch

Sanford medical supply maker wins grant

Sanford medical supply maker wins grant
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Maine , United-states , Ge-healthcare-life-sciences , National-science-foundation , Maine-manufacturing , Science-foundation , Life-sciences ,

Protein Purification and Isolation Market Poised to Achieve US$ 24.76 Billion by 2033-FMI Study

The global Protein Purification and Isolation Market is estimated to be worth US$ 9.03 billion by 2023, expanding at a modest CAGR of 10.6% from 2023 to 2033. By 2033, the market is projected to be valued at more than US$ 24.76 billion.The protein purification and isolation industry is driven by several key variable...

China , Delaware , United-states , Japan , New-york , Germany , Australia , India , America , Bio-rad-laboratories-inc , Greater-new-york-chamber

Luciferase Assays Market Poised to Surpass US$ 3 Billion by 2032-FMI Study

The luciferase assays market is divided geographically into seven regions: Asia-Pacific (excluding Japan), Eastern Europe, Western Europe, North America, Latin America, Middle East & Africa, and Eastern Europe. North America is expected to remain the dominating region, but Asia Pacific is expected to grow at the fas...

Russia , Poland , India , France , New-york , United-states , Delaware , Spain , Canada , China , Brazil , Italy

Transfection Technologies Market Size, Growth Drivers &Amp; Global Opportunities, 2031

Transfection Technologies Market Size, Growth Drivers &Amp; Global Opportunities, 2031
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Canada , Japan , France , Brazil , Saudi-arabia , Nigeria , Australia , Italy , South-africa , Russia , India , Mexico