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Global Next Generation Mass Spectrometer Industry

Global Next Generation Mass Spectrometer Industry is estimated to register 7.2% CAGR to reach US$ 4,097.1 million From 2022 to 2032

United-states , Japan , New-york , Delaware , America , Sciex-pte , Agilent-technologies , Market-insights-inc , Consumer-technology , Greater-new-york-chamber , Bruker-corporation , Jeol-ltd

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions1. TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impaired interneuron migration, activity-dependent dendrite retraction and an unanticipated persistent expression of exon 8A2–6. We reasoned that switching CACNA1C exon utilization from 8A to 8 would represent a potential therapeutic strategy. Here we developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells both in vitro and, following transplantation, in vivo. We discovered that the ASO-mediated switch from exon 8A to 8 robustly rescued defects in patient-derived cortical organoids and migration in forebrain assembloids. Leveraging a transplantation platform previously developed7, we found that a single intrathecal ASO administration rescued calcium changes and in vivo dendrite retraction of patient neurons, suggesting that suppression of CACNA1C exon 8A expression is a potential treatment for TS1. Broadly, these experiments illustrate how a multilevel, in vivo and in vitro stem cell model-based approach can identify strategies to reverse disease-relevant neural pathophysiology. Antisense oligonucleotides effectively decrease the inclusion of exon 8A of CACNA1C in human cells both in vitro and in rodents transplanted with human brain organoids, and a single intrathecal administration rescued both calcium changes and in vivo dendrite morphology of patient neurons.

Fiji , Leica-stellaris , Teledyne-lumenera , Mount-polysciences , Leica-microsystems , Takara-bio , Beckman-coulter , Perkinelmer , International-electric-company , Fisher-scientific , Stanford-university , Bruker-corp

Fabry Disease Treatment Market Report Latest Trends and Future Opportunities Analysis

Fabry Disease Treatment Market Report Latest Trends and Future Opportunities Analysis
sandiegosun.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sandiegosun.com Daily Mail and Mail on Sunday newspapers.

United-kingdom , Canada , South-korea , Argentina , United-states , Mexico , France , South-africa , Brazil , Germany , American , America

Posting Patient Prices: Transparency Cure for Hospital Blank Checks

Posting Patient Prices: Transparency Cure for Hospital Blank Checks
ricochet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from ricochet.com Daily Mail and Mail on Sunday newspapers.

United-states , Florida , Boston , Massachusetts , American , Americans , Cynthiaa-fisher , Joe-selvaggi , Cynthia-fisher , Ricochet-audio-network-superfeed , Perkinelmer , Ursinus-college

Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI

This preliminary descriptive report compares the rates of detecting high- and low-grade prostate cancer in men invited for prostate cancer screening vs

Helsinki , Eteläuomen-läi , Finland , Paris , France-general- , France , United-kingdom , Ronkainen , Northern-ostrobothnia , Sweden , Arvo , Kainuu-region

An in vitro neurogenetics platform for precision disease modeling in the mouse

An in vitro neurogenetics platform for precision disease modeling in the mouse
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Axion-biosystems , Matrigel-corning , Merck-millipore , Cayman-chemical-company , Summer-student-program , Perkinelmer , Committee-of-the-jackson-laboratory , A-haber-the-jackson-laboratory , National-institutes-of-health , Jackson-laboratory , Cell-signaling-technology , Use-committee

Visible Light Communication Market is Anticipated to Grow USD

Visible Light Communication Market is Anticipated to Grow USD
openpr.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from openpr.com Daily Mail and Mail on Sunday newspapers.

Japan , India , United-states , China , America , Sunny-optical-technology , Perkinelmer , Beckman-coulter , North-america , Southeast-asia , Thermo-fisher-scientific

Mobix Labs Broadens Product Portfolio to Include Medical Technology Sector

--End Users include GE HealthCare and PerkinElmer

...

California , United-states , Irvine , Fabian-battaglia , Ge-healthcare , Nasdaq , Mobix-lab , Mobix-labs-inc , Perkinelmer , Linkedin , Mobix-labs ,

Reproductive Genetics Market Analysis Report 2024-2032,

Dublin, March 28, 2024 (GLOBE NEWSWIRE) -- The

Bangkok , Krung-thep-mahanakhon , Thailand , Dublin , Ireland , United-states , South-africa , America , Natal , Perkinelmer , Laboratory-developed-tests

The Importance of Dairy Analysis Calibration

When it comes to the effective and efficient use of testing instruments to support the production of dairy products, dairy analysis calibration is key.

Jackie-trudell , Perkinelmer , Dairy-analysis , Sofia-karlberg , Sample-expertise , Results-plus , Dairy-analysis-calibration , Airy-analysis ,