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Functional genomics and systems biology in human neuroscience

Neuroscience research has entered a phase of key discoveries in the realm of neurogenomics owing to strong financial and intellectual support for resource building and tool development. The previous challenge of tissue heterogeneity has been met with the application of techniques that can profile individual cells at scale. Moreover, the ability to perturb genes, gene regulatory elements and neuronal activity in a cell-type-specific manner has been integrated with gene expression studies to uncover the functional underpinnings of the genome at a systems level. Although these insights have necessarily been grounded in model systems, we now have the opportunity to apply these approaches in humans and in human tissue, thanks to advances in human genetics, brain imaging and tissue collection. We acknowledge that there will probably always be limits to the extent to which we can apply the genomic tools developed in model systems to human neuroscience; however, as we describe in this Perspect ....

Le Bihan , Acta Neuropathol , Ng Development , Brain Initiative Cell Census Network , Foundational Data Initiative For Parkinson , N Accelerating Medicines Partnership , Stem Cell , Brain Initiative Cell Census , Tabula Sapiens , Nucleic Acids Res , Proteomics Bioinformatics , Cell Biol , United Kingdom Biobank , United Kingdom , Medicines Partnership , Foundational Data Initiative ,

Building the map for every cell of the human brain

To understand the human brain, an international consortium of scientists has created the most complete atlas of this organ to date. The map reveals the anatomy, the architecture of the tissues, how or where each cell is, their function, gene expression and regulation. ....

Science Advances , Brain Mapping , Brain Atlas , Single Cell Atlas , Brain Initiative Cell Census Network ,

A macroproject publishes a brain atlas, a map for understanding what makes us human

The research, which is akin to human genome sequencing, also explores the changes caused by neurological diseases ....

United States , New York , Czech Republic , Alyssa Weninger , Paola Arlotta , Johannes Kepler , Nikolas Jorstad , Isaac Newton , Juan Lerma , Nelson Johansen , Tycho Brahe , Paul Allen , Allen Institute , Spanish National Research Council , Allen Institute In Seattle , Harvard University , Brain Initiative Cell Census Network , University Of North Carolina , Us National Institutes Of Health , Allen Institute For Brain Science , Santiago Ram , North Carolina , Instituto De Neurociencias Alicante , Mount Sinai Hospital , Human Brain Project , Brain Science ,

Understanding the brain via a molecular map

Understanding the brain via a molecular map
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United States , Noah Snyder Mackler , Jay Shendure , Michael Platt , Kenneth Chiou , Arizona State University , University Of Pennsylvania , University Of Washington , Brotman Baty Institute , National Institutes , Brain Initiative Cell Census Network , Science Advances , Penn Integrates Knowledge , Brotman Baty ,

The Most Comprehensive Map of Human Brain Cells Revealed in New Study Published in 'Science'

The Most Comprehensive Map of Human Brain Cells Revealed in New Study Published in 'Science'
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United States , San Diego , Soult Ukpyolsi , South Korea , Yang Li , Mattia Maroso , Juyoung Lee , Paolo Arlotta , Kimberly Siletti , Bing Ren , Nelson Johansson , Brain Initiative Cell Census Network , Harvard University , American Association For The Advancement Of Science , Us National Institutes Of Health , University Of California , Allen Institute For Neuroscience , Yonhap News , Reporter Juyoung Lee , American Association , Brain Initiative Cell Census Network , Science Advances , Science Translational , Wei Tian , Allen Institute , Professor Bing Ren ,