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Searching for compounds with the therapeutic effects of ibogaine but not its toxicity, researchers found two that eased depression and opioid withdrawal. ....
Scientists have developed two new drug candidates for potentially treating addiction and depression, modeled on the pharmacology of a traditional African psychedelic plant medicine called ibogaine. ....
Computational docking strategy identifies selective SERT inhibitors that were 200 times more potent than the antidepressant fluoxetine, blunting symptoms in mice. ....