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African psychedelic plant medicine inspires new drug candidates for treating addiction and depression

Scientists have developed two new drug candidates for potentially treating addiction and depression, modeled on the pharmacology of a traditional African psychedelic plant medicine called ibogaine. ....

Brian Shoichet , Emily Henderson , Eisha Singh , Gary Rudnick , Allan Basbaum , Aashish Manglik , School Of Pharmacy , Sigma Aldrich , Bill Wetsel ,

African Psychedelic Plant Inspires Design of Antidepressant and Anti-Addiction Candidates

Computational docking strategy identifies selective SERT inhibitors that were 200 times more potent than the antidepressant fluoxetine, blunting symptoms in mice. ....

United States , San Francisco , Eisha Singh , Aashish Manglik , Allan Basbaum , Brian Shoichet , Gary Rudnick , Sigma Aldrich , School Of Pharmacy , University Of California , Bill Wetsel ,