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Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial

Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve health related quality of life compared with usual care in adults with post-covid-19 condition (long covid).

Design Pragmatic, multicentre, parallel group, superiority randomised controlled trial.

Setting England and Wales, with home based interventions delivered remotely online from a single trial hub.

Participants 585 adults (26-86 years) discharged from NHS hospitals at least three months previously after covid-19 and with ongoing physical and/or mental health sequelae (post-covid-19 condition), randomised (1:1.03) to receive the Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN (REGAIN) intervention (n=298) or usual care (n=287).

Interventions Best practice usual care was a single online session of advice and support with a trained practitioner. The REGAIN intervention was delivered online over eight ....

United Kingdom , Scott Mcguire , David Mcwilliams , Helen Atherton , Jonathon Prosser , Beatriz Lara , Martin Underwood , Patrick Sawdon , Francesca Denton , Rachel Potter , Peter Heine , Emma Padfield , Gordon Mcgregor , Nigel Edwards , Shilpa Patel , Sharisse Alleyne , Dalan Bush , Georgie Ray , Danielle Hale , Charles Abraham , Susanne Finnegan , Harbinder Sandhu , James Mason , Julie Bruce , Vivien Nichols , Rowena Williams ,

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care

Researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the UK NHS through the 100,000 Genomes Cancer Programme. ....

United Kingdom , Sequencin Hiseq , Cancer Programme , National Genomic Test Directory , Cambridge South Research Ethics Committee , Research Environment , National Cancer Registration , Analysis Service , Genomic Medicine Service , Genomes Cancer Programme , Public Health England , Office For National Statistics , National Genomic Research Library , International Organization For Standardization , United Kingdom National Healthcare System , Nature Medicine , National Healthcare System , Image Credit , United Kingdom Government , International Organization , Medicine Service , National Genomic Test , Sample Handling Guidance , Illumina Truseq Polymerase Chain Reaction , High Throughput Sequencin , Illumina North Star ,

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This randomized clinical trial assesses whether high-flow nasal cannula therapy is noninferior to continuous positive airway pressure for time to liberation fro ....

United Kingdom , United States , Northern Ireland , City Of , Richard Jenkin , Padmanabhan Ramnarayan , Bronagh Blackwood , Jennifer Whitty , Duncan Young , Christopher Seymour , Nealj Thomas , Robinder Khemani , Cormac Breatnach , Paul Mouncey , Madeleine Wang , United Kingdom National Institute For Health Research , Group Information , Department Of Surgery , National Health Service , United Kingdom Health Research Authority , National Institute For Health , Health Technology Assessment Programme , Cambridge South Research Ethics Committee , Imperial College London , Care Research , Line Support ,

Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial | Critical Care Medicine | JAMA

This clinical trial evaluates the noninferiority of high-flow nasal cannula (HFNC) therapy vs continuous positive airway pressure (CPAP) as the first-line mode ....

United Kingdom , City Of , Christopher Seymour , Padmanabhan Ramnarayan , United Kingdom National Institute For Health Research , Group Information , Paediatric Critical Care Society Study Group , Department Of Surgery , United Kingdom Health Research Authority , National Health Service , Health Technology Assessment , National Institute For Health Research , Cambridge South Research Ethics Committee , Imperial College London , Line Support , United Kingdom National Institute , Health Research , Clinical Trials Unit , United Kingdom Intensive Care National Audit , Health Service , Parental Stressor Scale , Size Calculation , Associate Editor , Pain Medicine , Intensive Care , Norfolk Place ,