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UCL: New immunotherapy insights for kidney cancer

Immune cell patterns have been discovered within tumours that can help predict if patients with kidney cancer will respond to immunotherapy, as part of a study co-led by researchers at UCL, the Francis Crick Institute and The Royal Marsden NHS Founda ....

United Kingdom , Emine Hatipoglu , Sergio Quezada , Samra Turajlic , Annie Vigneau Singh , Crick Cancer Dynamics Laboratory , Cancer Research United Kingdom , Cancer Dynamics Laboratory , Cancer Institute , Francis Crick Institute , Royal Marsden , Cancer Cell , Cancer Immunology ,

Cells Within the Center of a Tumor Are Most Likely To Metastasize


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Researchers from the Francis Crick Institute, Royal Marsden, UCL and Cruces University Hospital have found that cells from different parts of kidney tumours behave differently, and surprisingly, cells within the centre of a tumour are the most aggressive and have the highest chance of spreading around the body.
Cancers can spread to other parts of the body, with cells taking hold as secondary tumours which make the disease much harder to treat. Understanding the mechanics of this spread, a process called metastasis, could lead to new treatments that block this migration.
In their multidisciplinary study published today (17 May) in Nature Ecology and Evolution, scientists led by the Litchfield lab at UCL and the Turajlic, Swanton, and Bates labs at the Crick, analysed 756 cancer biopsy samples from different regions within tumours from the TRACERx Renal study. ....

Kevin Litchfield , Samra Turajlic , Cruces University Hospital , Crick Cancer Dynamics Laboratory , Cancer Institute , Francis Crick Institute , Royal Marsden , Nature Ecology , Cancer Dynamics Laboratory , Consultant Medical Oncologist , Chief Investigator , Nat Ecol , கெவின் லிட்ச்பீல்ட் , சிலுவைகள் பல்கலைக்கழகம் மருத்துவமனை , புற்றுநோய் நிறுவனம் , பிரான்சிஸ் கிரிக் நிறுவனம் , அரச மார்ஸ்டன் , இயற்கை சூழலியல் , ஆலோசகர் மருத்துவ புற்றுநோயியல் நிபுணர் , தலைமை புலனாய்வாளர் ,

Cells from centre of tumours most likely to spread around body – study


Cells from different parts of kidney tumours behave differently and those within the centre are the most aggressive and have the highest chance of spreading around the body, a new study has found.
Cancers can spread to other parts of the body, with cells taking hold as secondary tumours, making the disease much harder to treat.
Understanding the mechanics of this spread, a process called metastasis, could lead to new treatments that block this migration.
Scientists led by the Litchfield lab at UCL and the Turajlic, Swanton, and Bates labs at the the Francis Crick Institute analysed 756 cancer biopsy samples from different regions within tumours from the TRACERx Renal study. ....

United Kingdom , Kevin Litchfield , Samra Turajlic , Eu Framework Programme For Research , Cancer Institute , National Institute For Health Research , Biomedical Research Centre , Cancer Research United Kingdom , Crick Cancer Dynamics Laboratory , Institute Of Cancer Research , Francis Crick Institute , Cancer Dynamics Laboratory , Royal Marsden , Nature Ecology , Royal Marsden Renal Unit , Cancer Research , Rosetrees Trust , National Institute , Health Research , ஒன்றுபட்டது கிஂக்டம் , கெவின் லிட்ச்பீல்ட் , யூ கட்டமைப்பு ப்ரோக்ராம் க்கு ஆராய்ச்சி , புற்றுநோய் நிறுவனம் , தேசிய நிறுவனம் க்கு ஆரோக்கியம் ஆராய்ச்சி , உயிர் மருத்துவ ஆராய்ச்சி மையம் , புற்றுநோய் ஆராய்ச்சி ஒன்றுபட்டது கிஂக்டம் ,