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Extended lymph node removal does not benefit

An extended lymphadenectomy – removal of additional lymph nodes beyond the extent of the standard procedure – in patients undergoing radical cystectomy (removal of bladder and nearby tissues) because of clinically localized muscle-invasive bladder cancer provides no patient benefit as measured by disease-free survival or overall survival times. It does, however, increase the risk of adverse events (side effects) and post-surgical death. These primary results from the phase 3 SWOG S1011 clinical trial are being delivered in an oral presentation at the 2023 annual meeting of the American Society of Clinical Oncology in Chicago on June 5 (Abstract 4508). ....

United States , Franciscog Larosa , Ianm Thompson Jr , Ajai Alva , Sumantak Pal , Roberts Svatek , Adams Kibel , Wassim Kassouf , Kamal Pohar , Aashish Kamat , Sethp Lerner , Theresam Koppie , Arthuri Sagalowsky , Siamak Daneshmand , Catherine Tangen , Anne Schuckman , Dave Swalm , City Of Hope Medical Center , National Institutes Of Health , University Of Texas Health San Antonio , Stanford University , Md Anderson Cancer Center , Mcgill University Health Center , American Society Of Clinical Oncology , Ohio State University , Community Oncology Research Program ,

Cabozantinib most effective treatment for metastatic papillary kidney cancer


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IMAGE: Sumanta Pal, MD, a SWOG Cancer Research Network researcher and City of Hope physician, led a study that sets a new standard of care for metastatic papillary kidney cancer
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Credit: City of Hope
In a SWOG Cancer Research Network trial that put three targeted drugs to the test, the small molecule inhibitor cabozantinib was found most effective in treating patients with metastatic papillary kidney cancer - findings expected to change medical practice.
These findings will be presented at ASCO s virtual 2021 Genitourinary Cancers Symposium on Feb. 13, 2021 at 1 p.m. ET. The findings will be simultaneously published in ....

United States , Wayne State University , John Wright , Scott Cole , Los Angeles , Catherine Tangen , Ianm Thompson Jr , Naomi Balzer Haas , Danielj George , Georga Bjarnason , Mark Stein , Ulka Vaishampayan , Maria Tretiakova , Daniel Yc Heng , Brian Shuch , Adebowale Adeniran , Vivek Narayan , Primon Lara Jr , Sumanta Pal , Peter Humphrey , Ajjai Alva , National Cancer Institute , Cancer Therapy Evaluation Program , University Of Michigan , Exelixis Inc , Duke University Medical Center ,