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A codon usage analysis shows that Chinese kraits and king cobra snakes share more genetic similarities with SARS-CoV-2 than any other animal, including bats. Were venom peptides engineered into [...]
Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a devastating necrotizing skin disease. Key to its pathogenesis is mycolactone, the exotoxin virulence factor that is both immunosuppressive and cytotoxic. The discovery that the essential Sec61 translocon is the major cellular target of mycolactone explains much of the disease pathology, including the immune blockade. Sec61 inhibition leads to a loss in production of nearly all cytokines from monocytes, macrophages, dendritic cells and T cells, as well as antigen presentation pathway proteins and costimulatory molecules. However, there h...
Servicemembers are particularly at risk for Lyme disease; they live, work, and play on bases where Lyme is rampant. Some 75 percent of all U.S. military installations are located in states where 99 percent of the approximately 500,000 tickborne disease,