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Mechanical strain induces remodeling of the actin cytoskeleton, which is energetically costly. Salvi et al. uncovered a pathway that coupled mechanical strain to nutrient uptake. In MCF-10A breast cancer cells or MDCK epithelial cells, mechanical strain induced glucose uptake through the glucose transporter GLUT1 and increased the localization of GLUT1 at cell-cell junctions. GLUT1 bound to the cell-cell junction protein E-cadherin in MDCK cells in two- or three-dimensional culture. When exposed to force, cells reinforce the actin cytoskeleton in a process called cell stiffening. The authors...

DGAP-News: Atriva Therapeutics GmbH: Atriva Therapeutics to Speed up Development of COVID-19 Drug with Federal Funding Atriva Therapeutics to Speed up Development of COVID-19 Drug with Federal Funding 21.04.2021 / 16:03 Atriva Therapeutics to Speed up Development of COVID-19 Drug with Federal Funding German Federal Ministry of Education and Research (BMBF) awards Atriva up to €11.4 million for the clinical development of a drug to treat COVID-19 Product candidate ATR-002 could help hospital patients with COVID-19 avoid ventilation and intensive care treatment Targeting RNA viruses and a...

DGAP-News: Atriva Therapeutics GmbH: Atriva Therapeutics Announces Changes to Management Atriva Therapeutics Announces Changes to Management 13.04.2021 / 09:30 Atriva Therapeutics Announces Changes to Management - Olaf Althaus appointed Chief Financial Officer - Stephan Stenglein, M.D., recently joined as Chief Medical Officer - Proven track record and 20+ years of experience in their respective fields of expertise Tübingen (Germany), April 13, 2021 - Atriva Therapeutics GmbH, a biopharmaceutical company that is pioneering the development of host-targeting antiviral therapies, today announ...

Sun, 18 Oct 2020 19:56 UTC Since I started medical school in 1976, until 2020, I have heard the dogma that viral diseases are not treatable (with some exceptions such as antivirals for HIV/AIDS), certainly not with antimicrobials. My older son, a newly minted general surgeon, was educated much more recently, but with the same misunderstanding. Since viral diseases are not treatable, our only weapon is vaccination. A friend who spent his life as an academic university physician retiring in 2016 had never heard this fact either. As the "pandemic" broke out, I constantly watched and read online...

Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages. However, detailed analysis in...