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TRIM11 Regulates β-Catenin Pathway in vitro and in vivo To explore the underlying mechanism by which TRIM11 regulates gastric cancer, we did some literature research and found that several TRIM proteins can regulate β-catenin pathway, so we hypothesize that TRIM11 may regulate GC through β-catenin pathway. We detected the expression level of β-catenin in TRIM11 overexpression in MGC-803 cells and found that it was increased. Then, we further investigated the expression level of β-catenin downstream molecules and found that CyclinD1 and C-myc were upregulated and Axin2 were downregulated ...

30 values of each chemotherapeutic agent were applied in the further drug–drug interaction study (cisplatin: 10 μM for HeLa, 12 μM for SiHa; paclitaxel: 0.01 μM for HeLa, 0.006 μM for SiHa; 5-fluorouracil: 0.5 μM for HeLa, 50 μM for SiHa; doxorubicin: 0.075 μM for HeLa, 0.1 μM for SiHa). Figure 1 The effects of quercetin and cisplatin on the viability of cervical cancer cells. ( A and B) HeLa and SiHa were exposed to quercetin with various concentrations (0, 10, 20, 50, 100, 150 and 200 μM) for 24 h and 48 h, respectively; ( C and D) HeLa and SiHa were exposed to cisplatin with v...

1 1Department of Gastroenterology, Affiliated Dongtai Hospital of Nantong University, Dongtai, Jiangsu 224200, People’s Republic of China; 2Endoscopy Center, Affiliated Dongtai Hospital of Nantong University, Dongtai, Jiangsu 224200, People’s Republic of China Correspondence: Qi Jiang Department of Gastroenterology, Affiliated Dongtai Hospital of Nantong University, 2 Kangfuxi Road, Dongtai, Jiangsu 224200, People’s Republic of China Email qijiang2000@21cn.com Introduction: Colorectal cancer (CRC) is one of the most common human cancers and a leading cause of cancer-related death. Accu...

H) CCND1 expression in BC patients revealed by GEPIA website ( I) the β-catenin and GSK3β expression as well as the extent of GSK3β phosphorylation in MCF-7 and T47D parents and resistant cells. Data are displayed in the form of mean ± SD. All experiments were repeated at least three times. In panel ( B) two-way ANOVA along with Tukey’s multiple comparison was applied, while in panel ( D, E and p 0.05, ** p 0.01. Abbreviations: miR, microRNA; FOXO1, forkhead box O1; CCND1, cyclin D1; SD, standard deviation; ANOVA, analysis of variance. We predicted that FOXO1 could bind to the prom...