Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor
The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.
Source: news-medical.net
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RGCC/RGC-32, a Cell Cycle Protein Regulator, Protects Against Pulmonary Fibrosis
Previous research in tissue fibrosis has revealed the expression of a protein called either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein plays a profibrotic role (RGC-32). In contrast, the examination of publicly available gene expression datasets demonstrated a consistent drop in RGCC mRNA levels in people with pulmonary fibrosis. Researchers
Source: physiciansweekly.com
Arvinas and Pfizer Announce PROTAC Protein Degrader ARV-471 Continues to Demonstrate Encouraging Clinical Benefit Rate in Patients with Locally Advanced or Metastatic ER+/HER2- Breast Cancer
10.12.2021 - – ARV-471 continues to show a favorable tolerability profile and robust ER degradation in updated phase 1 dose escalation data presented at San Antonio Breast Cancer Symposium – – ARV-471 is expected to enter two Phase 3 registrational clinical ...
Source: wallstreet-online.de
Potential association between senescence and aging in COVID-19
A review published in Cells discussed characteristics of cellular senescence and its potential role in COVID-19.
Source: news-medical.net
TPGS2000-DOX prodrug micelles for improving BC therapy
TPGS2000-DOX prodrug micelles reverse the MDR of tumor cells, achieve passive targeting by forming nanomicelles, & enhance the efficacy & reduce DOC toxicity.
Source: dovepress.com