Circ_HIPK3 knockdown inhibits cell proliferation - CMAR
Circ_HIPK3 knockdown blocked cholangiocarcinoma malignant development partly via regulating the miR-148a-3p/ULK1 pathway
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Circ_HIPK3 knockdown blocked cholangiocarcinoma malignant development partly via regulating the miR-148a-3p/ULK1 pathway
USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H. Hartwell the 2001 Nobel Prize in Physiology or Medicine. A study led by Óscar Fernández-Capetill...
Study solves mystery of how cells measure their size Scientists have searched for years to understand how cells measure their size. Cell size is critical. It's what regulates cell division in a growing organism. When the microscopic structures double in size, they divide. One cell turns into two. Two cells turn into four. The process repeats until an organism has enough cells. And then it stops. Or at least it is supposed to. The complete chain of events that causes cell division to stop at the right time is what has confounded scientists. Beyond being a textbook problem, the question relates...
13–15 Calycosin is a fat-soluble component in the dried root of Astragalus membranaceus, which are organic compounds widely found in nature. Calycosin exerts various anti-tumor activities in vitro and in vivo, 16–18 but its mechanism of action in human GC cells is not clear. In this study, we evaluated the effects of calycosin on apoptosis, the cell cycle, and migration of GC cells under ROS regulation. In addition, we also determined the roles of MAPK/STAT3/NF-κB pathways in these processes. Materials and Methods Cell Lines and Cell Culture Twelve types of GC cells (AGS, KATO-3, MKN-28...
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