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Extreme dynamics in a biomolecular condensate

Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular condensates1–4. The functions of condensates span many length scales: they modulate interactions and chemical reactions at the molecular scale5, organize biochemical processes at the mesoscale6 and compartmentalize cells4. Understanding the underlying mechanisms of these processes will require detailed knowledge of the rich dynamics across these scales7. The mesoscopic dynamics of biomolecular condensates have been extensively characterized8, but their behaviour at the molecular scale has remained more elusive. Here, as an example of biomolecular phase separation, we study complex coacervates of two highly and oppositely charged disordered human proteins9. Their dense phase is 1,000 times more concentrated than the dilute phase, and the resulting percolated interaction network10 leads to a bulk viscosity 300 times greater than that of water. However, single-molec ....

United Kingdom , Molecular Properties , S Ys Resonance Energy , Ww Norton Company , Cell Biol , Acta Proteins , Matter Phys , Polymer Physics , Charged Macromolecules , Biological Systems , Theory Comput , Colloid Interface Sci , Der Meer , Energy Transfer , Advanced Transport Phenomena , Fluid Mechanics , Convective Transport Processes , Fluid Mech , Colloid Interfac , Depletion Interaction , Den Bosch , Polymer Dynamics ,

Nanostructure of the Anodic and Nanomaterials Sol-Gel Based Materials Application: Advances in Surface Engineering


anodic oxidation.  As a result,
one can obtain amorphous barrier-type oxides, crystalline barrier-type oxides or amorphous nanoporous oxides.  Currently, highly-ordered nanoporous anodic aluminum oxides (AAO) are obtained with various electrolytes to form nanostructures with a range of geometrical features.  This material can serve as a template for nanofabrication of variety of nanowires, nanotubes and nanodots.  In this way, porous alumina can be fabricated electrochemically through anodic oxidation of aluminum, yielding highly ordered arrays of nano-holes several hundreds down to several tens of nanometers in size.
Sol-gel chemistry offers a flexible approach to obtain a diverse range of materials.  It allows differing chemistries to be achieved as well as the ability to produce a wide range of nano-/micro-structures.  ....

New York , United States , United Kingdom , Comunidad Autonoma De Cataluna , Nano Lett , Xavier Albort Ventura , Boca Raton , R Van Noort , University Politecnic , Laboratory Electrochemical , Properties Of Silicic , Barcelona Spain Research , Barcelona International Trade Fair , University Of Barcelona Spain , J Nanoparticle Research , Industrial Cabrera De Mar , Reactive Ion Beam Etching , Ordered Array , Geometrically Controlled Nanodots Obtained , Anodic Porous Alumina , Targeted Drug Delivery Systems , Mesoporous Silica Nanoparticles , Microchip Nano Porous Interferometric Sensor , Biosensing Applications , Mesoporous Silica Materials , Controlled Drug Delivery ,