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The PAncreatic Surgery Composite Endpoint PACE – Development and Validation of a Clinically Relevant Endpoint Requiring Lower Sample Sizes.

To provide a composite endpoint in pancreatic surgery.Single endpoints in prospective and randomized studies have become impractical due to their low frequency and the marginal benefit of new interventions.Data from prospective studies were used to develop (n=1273) and validate (n=544) a composite endpoint based on postoperative pancreatic fistula, post-pancreatectomy hemorrhage as well as reoperation and ....

Wolters Kluwer Health Inc , Composite Endpoint , Wolters Kluwer Health ,

Ascendis Pharma A/S Announces Phase 3 PaTHway Trial of TransCon™ PTH in Adults with Hypoparathyroidism Met Primary and All Key Secondary Endpoints

– For the primary composite endpoint, TransCon PTH demonstrated a response rate of 78.7% compared to 4.8% for control . – TransCon PTH demonstrated statistically. | March 13, 2022 ....

United States , New Jersey , Palo Alto , Redwood City , Baden Wüberg , Aimee Shu , Ascendis Pharma , Melinda Baker , Tim Lee , Outcomes Trust Inc , Ascendis Pharma Group , Dial In International , Patti Bank , Ascendis Pharma Hp Patient Experience Research , Exchange Commission , Us Food Drug Administration For Transcon , European Union , European Medicines Agency , Globenewswire Inc , Clinical Development , Trial Top Line , Composite Endpoint , Key Pre Specified Secondary Endpoints , Hypoparathyroidism Patient Experience Scales , Physical Functioning , Daily Life ,

Ascendis Pharma A/S Announces Phase 3 PaTHway Trial of

– For the primary composite endpoint, TransCon PTH demonstrated a response rate of 78.7% compared to 4.8% for control (p-value <0.0001). – TransCon. ....

United States , New Jersey , Palo Alto , Redwood City , Baden Wüberg , Aimee Shu , Ascendis Pharma , Outcomes Trust Inc , Ascendis Pharma Group , Dial In International , Ascendis Pharma Hp Patient Experience Research , Exchange Commission , Us Food Drug Administration For Transcon , European Union , European Medicines Agency , Clinical Development , Trial Top Line , Composite Endpoint , Key Pre Specified Secondary Endpoints , Hypoparathyroidism Patient Experience Scales , Physical Functioning , Daily Life , Vice President , New Drug Application , Drug Administration , Marketing Authorisation Application ,