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Infect, replicate, and rapidly mutate: Computational virus modeling study

A new bioRxiv preprint study led by Barbara A Jones of IBM Research-Almaden in San Jose, California, used computational modeling to investigate how viruses rapidly mutate as well as how they respond or adapt to different host conditions. They observed a range of behaviors from glassy dynamics, bimodal quasispecies distributions, and periodic steady states. ....

United States , Barbaraa Jones , San Jose , Coronavirus Disease Covid 19 , Computational Modeling , Immune Response , Immune System , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new study shows that the ACE2 and RBD of coronavirus spike fragments have different binding strengths and dissociation rates when they are glycosylated and non-glycosylated. ....

Image Credit , Biophysical Journal , Coronavirus Disease Covid 19 , Ngiotensin Converting Enzyme 2 , Computational Modeling , Immune System , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein , Structural Protein ,

AlphaFold AI predicts SARS-CoV-2 omicron variant might not evade antibody neutralization

In a new study, scientists have computationally predicted the structure of the Omicron spike RBD from available sequences and explored the dynamics of antigen-antibody interactions. ....

South Africa , Lightspring Shutterstock , World Health Organization , University Of North Carolina , North Carolina , Spike Protein Receptor Binding Domain Structure , Neutralizing Antibody , Image Credit , Coronavirus Disease Covid 19 , Ars Cov 2 , Amino Acid , Binding Affinity , Computational Modeling , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Spike Protein ,

Patient-specific whole-heart computational models provide insights for personalized treatment

Whole-heart ventricular modeling has come a long way in recent years and is currently witnessing the evolution of a variety of computational approaches, especially within the realm of personalized technologies for patient-specific clinical applications. ....

Nataliaa Trayanova , Emily Henderson , Johns Hopkins University , Biophysics Reviews , Johns Hopkins , Biomedical Engineering , Computational Modeling ,

Hydroxychloroquine + Azithromycin therapy at a higher dose improved survival by nearly 200% in ventilated COVID patients

However, a fascinating new study posted to the medRxiv preprint server suggests that such disappointment may have been both premature and unwarranted, based on a re-analysis of over 250 patients on invasive mechanical ventilation (IMV) during the first two months of the pandemic. ....

New Jersey , United States , Saint Barnabas Medical Center , Liji Thomas , Observational Study , Ventilated Covid Patients , Image Credit , Lactate Dehydrogenase , Coronavirus Disease Covid 19 , Ars Cov 2 , Chronic Obstructive Pulmonary Disease , Computational Modeling , Convalescent Plasma , D Dimer , புதியது ஜெர்சி , ஒன்றுபட்டது மாநிலங்களில் , துறவி பர்னபாஸ் மருத்துவ மையம் , அவதானிப்பு படிப்பு , படம் கடன் ,