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1. In this observational study, patients in high remote patient monitoring (RPM) practices had better hypertension outcomes than those at matched low-RPM practices. 2. Patients in high-RPM practices had more primary care physician outpatient visits and total hypertension-related spending. Evidence Rating Level: 2 (Good) Study Rundown: RPM is a healthcare delivery method where clinicians monitor

1. In this randomized controlled trial, the combination of vancomycin with cefazolin was not superior to surgical antimicrobial prophylaxis with cefazolin alone in patients undergoing arthroplasty. 2. Prophylaxis with vancomycin and cefazolin was associated with an increased risk of hypersensitivity reactions and decreased risk of acute kidney injury (AKI) compared to cefazolin alone. Evidence Rating

1. In these two randomized parallel-group trials, the use of gantenerumab did not lead to slower cognitive decline over 116 weeks among persons with early symptomatic Alzheimer’s disease compared to placebo. 2. After 116 weeks, gantenerumab was associated with lower amyloid plaque burden than the placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: The accumulation

1. In this randomized controlled trial, universal decolonization with topical antiseptics significantly reduced the risks of hospitalization due to infection among nursing home residents as compared to routine care. 2. The number needed to treat (NNT) was 9.7 to prevent one hospitalization due to infection in the nursing home setting. Evidence Rating Level: 2 (Good)

A retrospective analysis of more than 1 million hospitalizations provides insight into the impact of hepatitis C virus infection and cirrhosis on mortality risk in patients hospitalized with COVID-19.