Live Breaking News & Updates on Australian surgical antibiotic prophylaxis

Vancomycin and cefazolin not superior to cefazolin alone in arthroplasty prophylaxis

1. In this randomized controlled trial, the combination of vancomycin with cefazolin was not superior to surgical antimicrobial prophylaxis with cefazolin alone in patients undergoing arthroplasty. 2. Prophylaxis with vancomycin and cefazolin was associated with an increased risk of hypersensitivity reactions and decreased risk of acute kidney injury (AKI) compared to cefazolin alone. Evidence Rating

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Trial finds additional antibiotics don't protect against joint replacement infection

Trial finds additional antibiotics don't protect against joint replacement infection
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Beefed-Up Antibiotic Prophylaxis No Help for Post-Arthroplasty Infections

And adding vancomycin to cefazolin may have increased surgical-site infections after knee surgery

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More is not better: Trial finds giving more antibiotics to prevent joint replacement infections doesn't help

More is not better: Trial finds giving more antibiotics to prevent joint replacement infections doesn't help
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Trial: Extra Antibiotics Fail to Prevent Joint Replacement Infections

Trial: Extra Antibiotics Fail to Prevent Joint Replacement Infections
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