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SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 provides guidance for clinical trial protocol writing. However, neither the original guidance nor its extensions adequately cover the features of early phase dose-finding trials. The SPIRIT Dose-finding Extension (DEFINE) statement is a new guideline that provides recommendations for essential items that should be provided in the protocols of these trials. It details extensions to the SPIRIT 2013 guidance, incorporating 17 new items and modifying 15 existing items. The purpose of this guideline is to promote trans...

TURIN, Italy, Sept. 25, 2023 (GLOBE NEWSWIRE) -- Everything is ready for the Monaco Smart & Sustainable Marina Rendezvous. Organised by Mona...

All events are online and free unless stated otherwise. Every Saturday 10:30 am. Climate Mobilization Coalition Zoom Meeting. April 2nd, 9th, 16th, 23rd, and 30th. April 6th Wednesday 5:30 pm - 7 pm Public Surveillance vs. Personal Privacy April 7th Thursday 1 pm - 2 pm Achieving Green Infrastructure in San Diego April 9th Saturday…

Published results showed plasma D-dimer was noninferior to serum C-reactive protein and erythrocyte sedimentation rate in the diagnosis of periprosthetic joint infection.“This study demonstrated that plasma D-dimer had comparable diagnostic accuracy to traditional inflammatory markers, such as CRP and [erythrocyte sedimentation rate] ESR, in the diagnosis of PJI,” Saad Tarabichi, MD,

Measurement of plasma D-dimer levels – a test more commonly used to detect blood-clotting disorders – can provide useful information when making the difficult diagnosis of periprosthetic joint infection (PJI), reports a study in The Journal of Bone & Joint Surgery.