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Rolling Stone Could Psilocybin Be as Effective as Antidepressants? A small study indicates that psilocybin, the active compound in psychedelic mushrooms, could have similar effects to pharmaceuticals By Jahi Chikwendiu/The Washington Post/Getty Images Over the past few years, there has been an emerging body of evidence that psylocybin, or the active compound in magic mushrooms, could serve as a potentially effective treatment for major depressive disorder. On Wednesday, the New England Journal of Medicine added to that body of research with a small study from Imperial College London, which indicated that psilocybin could potentially be a more efficient, and equally effective, treatment for depression as a common antidepressant. ....