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Antiviral T cells safe, effective as off-the-shelf therapy for painful complication after stem cell transplants A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the Journal of Clinical Oncology. Infusion of T cells targeting BKV resulted in rapid resp...

Researchers develop first 3D organoid models of the pancreas from human stem cells This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, it's frequently diagnosed after the disease has progressed too far for surgical intervention and/or has spread throughout the body. Research indicates that earlier detection of pancreatic tumors could quadruple surv...

Physical and mental health decline associated with more pronounced cognitive disengagement A recent study suggests that preserving physical and mental health helps older adults experiencing cognitive impairment stave off declines in cognitive engagement. We found that declines in physical and mental health were associated with more pronounced cognitive disengagement. The impact of declines in physical health was particularly pronounced for study participants who had more advanced cognitive impairment to begin with." Shevaun Neupert, Study's Corresponding Author and Professor of Psychology, No...

Memory and executive function symptoms are valuable for predicting CTE pathology, suggests study Diagnosing Chronic Traumatic Encephalopathy (CTE) during life is crucial for developing therapies and for determining how common the disease is among individuals exposed to repetitive head impacts from contact sports, military service and physical violence. While the ability to diagnose CTE prior to death has remained elusive, researchers from Boston University School of Medicine (BUSM) for the first time have shown that progressive memory loss and issues with executive function, the ability to fo...

Tibetan Plateau may Warm Faster in Future than Projected by Climate Models Written by AZoCleantechApr 7 2021 Over the last few decades, the Tibetan Plateau, called 'the roof of the world,' has warmed up more quickly compared to the global average. Projected future warming of the Tibetan Plateau in the CMIP5 ensemble. The thick curves indicate the multi-model ensemble means and the shadings denote the 90% model intervals, derived from the raw model output. The dashed curves indicate the constrained projections based on the attribution result. Blue and red represent a medium (RCP4.5) and high ...