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Deep learning-based splice-AI can help predict the onset of Alzheimer's disease

Deep learning-based splice-AI can help predict the onset of Alzheimer s disease
Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.
This research outcome was published in
PNAS, a world-renowned academic journal.
Prediction of Alzheimer s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening
Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders. ....

South Korea , Suh Pann Ghill , Jae Yeol Joo , Emily Henderson , Korea Brain Research Institute , Brain Research Institute , President Suh Pann Ghill , Deep Learning Based Approach , Fourth Industrial Revolution , Alzheimer 39s Disease , Deep Learning , Amino Acid , Corona Virus , Gene Expression , High Throughput Screening , Phospholipase C , தெற்கு கொரியா , எமிலி ஹென்டர்சன் , கொரியா மூளை ஆராய்ச்சி நிறுவனம் , மூளை ஆராய்ச்சி நிறுவனம் , ஆழமான கற்றல் அடிப்படையிலானது அணுகுமுறை , நான்காவது தொழில்துறை புரட்சி , ஆழமான கற்றல் , அமினோ அமிலம் , கொரோனா வைரஸ் , கீந் வெளிப்பாடு ,

Study indicates neural pathway that provides pain relief, reduces cravings for opioids

Study indicates neural pathway that provides pain relief, reduces cravings for opioids
Researchers have discovered that there may be a new pathway in the brain that provides pain relief and reduces cravings for opioids.
Over a third of the U.S. population suffers from chronic pain, with little to no reported relief from medication. Transcranial magnetic brain stimulation (TMS) is a noninvasive form of brain stimulation that may offer a new treatment option for these underserved members of our community.
In a recent paper in
Drug and Alcohol Dependence, researchers at the Medical University of South Carolina evaluated two different strategies for relieving pain with TMS: applying TMS to the motor cortex and the dorsolateral prefrontal cortex (DLPFC). ....

Colleen Hanlon , Julia Imperatore , Emily Henderson , Wake Forest School Of Medicine , University Of South Carolina , Department Of Psychiatry , Alcohol Dependence , Medical University , South Carolina , Principal Investigator , Wake Forest School , Brain Stimulation , Chronic Pain , Magnetic Brain Stimulation , சக ஹன்லான் , எமிலி ஹென்டர்சன் , எழுந்திரு காடு பள்ளி ஆஃப் மருந்து , பல்கலைக்கழகம் ஆஃப் தெற்கு கரோலினா , துறை ஆஃப் மனநல மருத்துவம் , ஆல்கஹால் சார்பு , மருத்துவ பல்கலைக்கழகம் , தெற்கு கரோலினா , ப்ரிந்ஸிபல் புலனாய்வாளர் , எழுந்திரு காடு பள்ளி , மூளை ஸ்டிம்யுலேஶந் , நாள்பட்ட வலி ,

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain

Neuroinvasiveness of SARS-CoV-2 shown by viral RNA and inflammation in the brain
The coronavirus disease 2019 (COVID-19) pandemic has claimed well over 2.4 million lives, but its long-term sequelae are still being identified. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an infection that may be associated with a wide spectrum of disease, from asymptomatic to critical or terminal respiratory failure or multi-organ dysfunction.
A new preprint on the
bioRxiv server describes the results of a macaque study that showed the development of neurological features of inflammation, following infection by SARS-CoV-2.
Neurological symptoms in SARS-CoV-2 infection
SARS-CoV-2 primarily affects the respiratory organs, but in about a third of hospitalized COVID-19 patients, neurological manifestations are present. These include anosmia or dysgeusia, delirium, impaired consciousness, seizures, or psychosis. Some patients also develop Parkinsonism. ....

Liji Thomas , Coronavirus Disease Covid 19 , Sars Cov 2 , Corona Virus , Lewy Bodies , Pituitary Gland , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கொரோனா வைரஸ் , மோசமான உடல்கள் , வளர்சிதை மாற்றம் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Researchers identify a neural pathway critical to correcting behavioral errors

Researchers identify a neural pathway critical to correcting behavioral errors
Mount Sinai researchers have identified a neural pathway through which the brain detects errors and guides subsequent behavioral improvement. This process, called cognitive control, is frequently dysregulated in a wide range of psychiatric disorders.
The team s research, published February 19 in
Neuron, also suggests that neurostimulation of this brain pathway could provide an important mechanism for attention adjustments following behavioral errors.
When errors are committed, such as missing a stop sign or running a red light while driving, it s important for our survival to immediately adapt behavior by paying more attention to prevent further errors. This ability to adapt behavior after erroneous actions are one of the key components of human cognitive control. ....

Kevin Norman , Hirofumi Morishita , Emily Henderson , Icahn School Of Medicine At Mount Sinai , Development Institute , Mindich Child Health , Friedman Brain Institute , Associate Professor , Icahn School , Mount Sinai , Study Senior Author , Faculty Member , கெவின் நார்மன் , ஹிரோபூமி மோரிஷிதா , எமிலி ஹென்டர்சன் , இக்ஹ்ன் பள்ளி ஆஃப் மருந்து இல் ஏற்ற சினை , வளர்ச்சி நிறுவனம் , ப்ரைட்மேன் மூளை நிறுவனம் , இணை ப்ரொஃபெஸர் , இக்ஹ்ன் பள்ளி , ஏற்ற சினை , படிப்பு மூத்தவர் நூலாசிரியர் , ஆசிரிய உறுப்பினர் , மன இறுக்கம் , மனநல மருத்துவம் ,

Neurons activated by visual stimulus keep more active during subsequent sleep, study shows

Neurons activated by visual stimulus keep more active during subsequent sleep, study shows
When you slip into sleep, it s easy to imagine that your brain shuts down, but University of Michigan research suggests that groups of neurons activated during prior learning keep humming, tattooing memories into your brain.
U-M researchers have been studying how memories associated with a specific sensory event are formed and stored in mice. In a study conducted prior to the coronavirus pandemic and recently published in
Nature Communications, the researchers examined how a fearful memory formed in relation to a specific visual stimulus.
They found that not only did the neurons activated by the visual stimulus keep more active during subsequent sleep, sleep is vital to their ability to connect the fear memory to the sensory event. ....

United States , Brittany Clawson , Sara Aton , Emily Henderson , Um Department Of Molecular , Nature Communications , University Of Michigan , Um Department , Corona Virus , ஒன்றுபட்டது மாநிலங்களில் , பிரிட்டானி கிளாசன் , சாரா ஆதொன் , எமிலி ஹென்டர்சன் , உம் துறை ஆஃப் மூலக்கூறு , இயற்கை தகவல்தொடர்புகள் , பல்கலைக்கழகம் ஆஃப் மிச்சிகன் , உம் துறை , கொரோனா வைரஸ் , சர்வதேச பரவல் ,