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Higher T-Cell Inflamed GEP Values Are Positively Associated with Outcomes For Pembrolizumab/Axitinib in ccRCC

Higher T-cell inflamed GEP values were positively associated with clinical outcomes for pembrolizumab plus axitinib in advanced clear cell RCC. ....

United States , Brian Rini , International Metastatic , Vanderbilt Ingram Cancer Center , Ingram Professor Of Cancer Research , Database Consortium , Highert Cell , Clinical Trials , Ingram Professor , Cancer Research , Baseline Patient , North America , Western Europe , Findings From ,

Lenvatinib/Pembrolizumab Yields Greater Clinical Benefit vs Sunitinib Regardless of Biomarker Subtypes in ccRCC

Lenvatinib plus pembrolizumab displayed a superior clinical benefit vs sunitinib irrespective of patient biomarker subtype in advanced clear cell RCC. ....

United States , Dana Farber Cancer Institute , Toni Choueiri , Nancy Kohlberg , Memorial Sloan Kettering Cancer Center , International Metastatic , Database Consortium , Professor Of Medicine At Harvard Medical School , Lank Center , Genitourinary Oncology At Dana Farber Cancer Institute , Genitourinary Oncology , Kidney Cancer Program , Harvard Cancer Center , Nancy Kohlberg Chair , Harvard Medical School , Western Europe , North America ,

ASCO 2024: Belzutifan in Patients with Advanced Clear Cell Renal Cell Carcinoma: Subgroup Analysis of the Phase 2 LITESPARK-013 Study

ASCO 2024, advanced clear cell renal cell carcinoma (ccRCC), Belzutifan, LITESPARK-013 Study, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI). ....

United States , Georgetown University , District Of Columbia , Michael Atkins , Michaelb Atkins , University Of Toronto , Georgetown Lombardi Comprehensive Cancer Center , Department Of Medical Oncology , Database Consortium , Georgetown University Medical Center , Merck Sharp Dome , Society Of Urologic Oncology , International Metastatic , American Society Of Clinical Oncology , Clinical Oncology , Annual Meeting , Deputy Director , Scholl Professor , Vice Chair , Medical Oncology , Rashid Sayyid , Urologic Oncology , Clinical Fellow ,

DFF332 Elicits Efficacy and Is Safe in Advanced Clear Cell RCC

The small molecule inhibitor DFF332 elicited clinical activity and had a tolerable safety profile in patients with advanced clear cell renal cell carcinoma. ....

United States , Sumanta Kumar Pal , Bladder Cancer Disease Team , Kidney Cancer Program , Database Consortium , International Metastatic , Medical Oncology , Therapeutics Research , Hope Comprehensive Cancer Center ,

ASCO: Merck KGaA's Bavencio combo misses survival mark in RCC

Although the overall survival miss won't cost Bavencio its FDA approval, it puts the drug further behind rival PD-1 combos from Merck & Co. and BMS. ....

New York , United States , Merck Keytruda , Keytruda Lenvima , Peter Guenter , Exelixi Cabometyx , Merck Kgaa Bavencio , International Metastatic , Merck Kgaa , Bristol Myers Squibb , Merck Kga , American Society Of Clinical Oncology , Database Consortium , Merck Co , American Society , Clinical Oncology , Bristol Myers , Fierce Pharma ,