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Dynamics of sputum conversion during effective tuberculosis treatment: A systematic review and meta-analysis

Author summary Why was this study done? Though cited in many countries’ national guidance, the evidence that individuals with pulmonary tuberculosis (TB) are rendered non-infectious by 2 weeks of effective TB treatment is challenged. This systematic review was commissioned by the World Health Organization to provide evidence to inform TB infection prevention and control guidelines. We sought to synthesise the available data on the clearance of potentially infectious TB bacteria from the sputum of patients after starting effective treatment. What did the researchers do and find? We performed systematic searches of literature databases to identify relevant articles, using predetermined inclusion criteria. Extracted data were synthesised using narrative summaries and meta-analyses. A minority of patients had clearance of TB bacteria from sputum at 2 weeks of effective treatment, as assessed by either sputum smear or culture. As expected, the proportion having cleared TB bacter ....

United States , Mengyun Liu , Maria Krutikov , Fuad Mirzayev , Guideline Development Group , Global Health , Lshtm Tb Centre , World Health Organization , Global Tb Department Guideline Development Group , Department Of Global Tb Programme , South America , North America , Creative Commons Attribution License , World Health , Alice Gonz , Mycobacterium Tuberculosis , Drug Therapy , Randomized Controlled Trials , Database Searching , Respiratory Infections , Systematic Reviews , ஒன்றுபட்டது மாநிலங்களில் , வழிகாட்டல் வளர்ச்சி குழு , உலகளாவிய ஆரோக்கியம் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , தெற்கு அமெரிக்கா ,