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Frontiers | Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

In mammals, the relationship between the immune system and behavior is widely studied. In fish, however, the knowledge concerning the brain immune response and behavioral changes during brain viral infection is very limited. To further investigate this subject, we used the model of tilapia lake virus (TiLV) infection of zebrafish (Danio rerio), which was previously developed in our laboratory. We demonstrated that TiLV persists in the brain of adult zebrafish for at least 90 days, even when the virus is not detectable in other peripheral organs. The virions were found in the whole brain. During TiLV infection, zebrafish displayed a clear sickness behavior: decreased locomotor activity, reduced food intake, and primarily localizes near the bottom zone of aquaria. Moreover, during swimming individual fish exhibited also unusual spiral movement patterns. Gene expression study revealed that TiLV induces in the brain of adult fish strong anti-viral and inflammatory response and up-regulates ....

United States , Baden Wüberg , Noord Brabant , Novoab Nodavirus , Albert Willemsen Noldus , Oreochromis Niloticus , Oncorhynchus Mykiss , Le Clerc , Clin Microbiol , Pons Garcia , Carassius Auratus , Calcarifer Bloch , Gen Virol , Weissella Cibaria , Kembou Tsofack , Carlos Kreutz , Gray Oreochromis Niloticus , Anim Health Res Rev , Microglia In Development , Jagiellonian University In Krakow , Priority Research Area Bio , Kinga Sawa Jagiellonian University , Zebrafish Models For Translational Neuroscience Research , Research University , Ethics Committee In Krak , Excellence Initiative ,

Foot and Mouth Disease vaccine development and challenges

Foot and Mouth Disease vaccine development and challenges
dovepress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dovepress.com Daily Mail and Mail on Sunday newspapers.

Republic Of , South Africa , College Of Veterinary Medicine , Ash Sharqiyah , Northern Cape , South African , Microb Pathog , Liuy Research , University Of Gondar , Animal Sciences , Binary Ethylenemines , Cytotoxict Cells , Monocytes Colony , South African Type , Veterinary Medicine , Microbiol Resour , Dev Biol , Mol Biol , Cattle Against Foot And Mouth Disease , Foot Mouth Dis Virus ,