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Roche launches automated serology hepatitis E virus tests, including a test to detect acute HEV infections, recommended in the new WHO 2023 Essential Diagnostics List

Roche launches automated serology hepatitis E virus tests, including a test to detect acute HEV infections, recommended in the new WHO 2023 Essential Diagnostics List
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United States , Saudi Arabia , Sileia Urech , Gerard Tobin , Genet Evol , Rebekka Schnell , Simon Goldsborough , Kirti Pandey , Clin Virol , Bruno Eschli , Birgit Masjost , Sabine Borngr , Matt Sause , Nathalie Altermatt , Karsten Kleine , Loren Kalm , J Gen Virol , World Health Organization , United Nations , World Health Organisation , Roche Group , European Association , Diagnostics List , Vitro Diagnostics , Dow Jones Sustainability Indices , Chugai Pharmaceutical ,

Frontiers | Vaccination With a Gamma Irradiation-Inactivated African Swine Fever Virus Is Safe But Does Not Protect Against a Challenge

African swine fever (ASF) is among the most devastating viral diseases of pigs and wild boar worldwide. In recent years, the disease has spread alarmingly. Despite intensive research activities, a commercialized vaccine is still not available, and efficacious live attenuated vaccine candidates raise safety concerns. From a safety perspective, inactivated preparations would be most favourable. However, both historical and more recent trials with chemical inactivation did not show an appreciable protective effect. Under the assumption that the integrity of viral particles could enhance presentation of antigens, we used gamma irradiation for inactivation. To this means, gamma irradiated ASFV “Estonia 2014” was adjuvanted with either Polygen™ or Montanide™ ISA 201 VG, respectively. Subsequently, five weaner pigs per preparation were immunized twice with a three-week interval. Six weeks after the first immunization, all animals were challenged with the highly virulent ASFV strain ....

Nordrhein Westfalen , United States , Bad Homburg , San Diego , La Garenne Colombes , France General , Kirovskaya Oblast , Krasnodarskiy Kray , Mecklenburg Vorpommern , Vila Real , Mariy El , Steffen Brenz , Neospora Caninum Tachyzoite , Ulrike Kleinert , Ghalyan Chi Langroudi , Petra Meyer , Sebastien Deville , Robin Brandt , Silvia Schuparis , Eimeria Acervulina , Gen Virol , Domenique Lux , Deutschland Gmb , Matthias Jahn , Microbiol Spectr , Hoffmannb Development ,