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Mutation-induced DNMT1 cleavage drives neurodegenerative disease

Mutation-induced DNMT1 cleavage drives neurodegenerative disease
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

Jialun Li , Rocky Hill , Jackson Immunoresearch , Cyagen Biosciences Inc , Accreditation Of Laboratory Animal Care , Cell Signaling Technology , China Normal University , Association For Assessment , Associates Inc , Ministry Of Science , Committee Of Zhejiang University , National Natural Science Foundation Of China , China Normal University Center , Development Program Of China , Ali Laboratory , Fudan University , Animal Research , National Key Research , Wako Pure Chemicals Industries Ltd , Technology Of China , East China Normal , Cyagen Biosciences , Laboratory Animal Care , East China Normal University Center , Institutional Animal Care , Use Committee ,

A dual-phase alloy with ultrahigh strength-ductility synergy over a wide temperature range

High-entropy alloys (HEAs), as an emerging class of materials, have pointed a pathway in developing alloys with interesting property combinations. Although they are not exempted from the strength-ductility trade-off, they present a standing chance in overcoming this challenge. Here, we report results for a precipitation-strengthening strategy, by tuning composition to design a CoNiV-based face-centered cubic/B2 duplex HEA. This alloy sustains ultrahigh gigapascal-level tensile yield strengths and excellent ductility from cryogenic to elevated temperatures. The highest specific yield strength (~150.2 MPa·cm3/g) among reported ductile HEAs is obtained. The ability of the alloy presented here to sustain this excellent strength-ductility synergy over a wide temperature range is aided by multiple deformation mechanisms i.e., twins, stacking faults, dynamic strain aging, and dynamic recrystallization. Our results open the avenue for designing precipitation-strengthened lightweight HEAs with ....

Natural Science Foundation Of Zhejiang Province , National Natural Science Foundation Of China , National Key Research , Research Funds For The Central Universities , Development Program Of China , Mettler Toledo , Shanghai Synchrotron Radiation , Zeiss Supra , Imaging Microscopy , Creative Commons Attribution Noncommercial , National Natural Science Foundation , Development Program , Natural Science Foundation , Zhejiang Province , Fundamental Research Funds , Central Universities ,

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study
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Jin Yin Tan , United Kingdom , National Natural Science Foundation Of China , Jack Ma Foundation , British Medical Research Council , Elsevier Ltd , Development Program Of China , National Key Research , Sunshine Charity Foundation , Major Projects Of National Science , Development Of Pulmonary Tuberculosis , Ping An Insurance Group , China Evergrande Group , Jin Yin Tan Hospital , Medical Sciences Innovation Fund , Medical Sciences , National Natural Science Foundation , Development Program , Major Projects , National Science , New Drug Creation , Pulmonary Tuberculosis , Sino Biopharmaceutical , Ping An Insurance , New Sunshine Charity , Chinese Academy ,

Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy

Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy
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United States , United Kingdom , Guangdong Zhou , Shanghai Jiao Tong University School Of Medicine , China Postdoctoral Science Foundation , Division Of Laboratory Animal Medicine , Shanghai Jiagan Biological Technology Co , Program Of Shanghai Technology Research Leader , Ethics Committee Of Shanghai Ninth People Hospital , Development Program Of China , National Nature Science Foundation Of China , Worthington Biochemical Corp , Technology Major , National Key Research , Alcian Blue , High Definition Camera System , Shanghai Jiao Tong University School , Applied Biosystems , Independent Ethics Committee , Shanghai Ninth People , Laboratory Animal , Creative Commons Attribution Noncommercial , Development Program , National Nature Science Foundation , Shanghai Municipal Science , Technology Major Project ,

Interaction between Climatic Factors and Timescale Affect Assessment of Extreme Drought in China

Interaction between Climatic Factors and Timescale Affect Assessment of Extreme Drought in China
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Tibetan Plateau , China General , Natural Science Foundation Of China , Atmospheric Research , Institute Of Applied Ecology , National Key Research , Landscape Processes Group , Development Program Of China , Chinese Academy Of Sciences , Applied Ecology , Chinese Academy , Development Program , Natural Science Foundation ,