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Since the beginning of the COVID-19 pandemic, in-utero transmission of SARS-CoV-2 remains a rarity and only very few cases have been proven across the world. Here we depict the clinical, laboratory and radiologic findings of preterm triplets born at 28 6/7 weeks to a mother who contracted COVID-19 just one week before delivery. The triplets showed SARS-CoV-2 positivity right after birth, developed significant leukopenia and early-onset pulmonary interstitial emphysema. The most severely affected triplet I required ten days of high-frequency oscillatory ventilation due to failure of conventional invasive ventilation, and circulatory support for four days. Despite a severe clinical course in two triplets (triplet I and III), clinical management without experimental, targeted antiviral drugs was successful. At discharge home, the triplets showed no signs of neurologic or pulmonary sequelae. Placental immunohistology with SARS-CoV-2 N-protein localized strongly to syncytiotrophoblast cells ....

South Korea , New York , United States , Soult Ukpyolsi , United Kingdom , South Korea General , Baden Wüberg , Prenat Diagn , Al Aisari , Saif Al , Al Yahmadi , Institute For Pathology At Weiden Hospital , Laboratory Workup , Pediatric Neurodevelopmental Center , Arch Pathol Lab , Claypool Life Sciences , World Health Organization , Lancet Child Adolesc Health , Wolters Kluwer Health Lippincott Williams Wilkins , Ventana Medical Systems , Disease Severity With , Pediatric Neurodevelopmental , Weiden Hospital , Severe Acute Respiratory Syndrome Coronavirus , Child Adolesc , Med Abstract ,