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Subgroup Analysis Shows Dostarlimab/Chemotherapy Elicits PFS Benefit in dMMR/MSI-H, TP53+, and NSMP Endometrial Cancer

Patients with primary advanced or recurrent endometrial cancer whose disease was deficient mismatch repair/microsatellite instability-high, TP53 mutated, or had no specific molecular profile, experienced a survival benefit when treated with dostarlimab-gxly plus chemotherapy vs placebo plus chemotherapy. ....

Mansoor Raza Mirza , European Society Of Medical Oncology , European Society , Medical Oncology , Endometrial Cancer , Esmo Congress , Ruby Trial ,

UK woman declared cancer-free, thanks to new 'miracle drug'

A civil servant in Wales has become the first person in the country to be prescribed a new drug, dostarlimab, for colorectal cancer. The 42-year-old was diagnosed with bowel cancer a year ago and received dostarlimab infusions for six months. Tests have shown that there is no longer any evidence of the disease. ....

United Kingdom , Craig Barrington , Janet Baker , Carrie Downey , Offering College , Swansea Bay University Health Board , Healthcare Management Analytics Programme , Swansea Bay University Health , Healthcare Expertise , Cancer Wonder Drug Dostarlimab , Cancer Miracle Drug Dostarlimab , Bowel Cancer , Colorectal Cancer ,

UK Woman Declared All-Clear From Cancer Thanks To 'Miracle' Drug

The 42-year-old civil servant was diagnosed a year ago and given dostarlimab infusions for six months. ....

United Kingdom , Craig Barrington , Carrie Downey , Swansea Bay University Health Board , Miracle Drug , Singleton Hospital , Woman Cancer Free After Miracle Drug ,

Dostarlimab/Chemo Approval Changes Treatment Paradigm for dMMR/MSI-H Advanced or Recurrent Endometrial Cancer

Dana Chase, MD, FACOG, discusses key efficacy, safety, and quality of life data from the RUBY trial supporting the FDA approval of dostarlimab and explains how this approval could help improve the efficacy of current chemotherapy regimens in advanced-stage or recurrent endometrial cancer. ....

Dana Chase , Phase 3 Ruby Engot En6 Gog3031 Nsgo Trial Nct03981796 , Fda Approval , Mismatch Repair Deficient Dmmr Or Microsatellite Instability High Msih Advanced Recurrent Endometrial Cancer ,

FDA Approves Dostarlimab Plus Chemo for dMMR/MSI-H Primary Advanced or Recurrent Endometrial Cancer

The FDA has approved dostarlimab-gxly (Jemperli) in combination with carboplatin and paclitaxel, followed by dostarlimab as a monotherapy in adult patients with primary advanced or recurrent endometrial cancer that is mismatch repair deficient, as determined by an FDA-approved test, or microsatellite instability high. ....

United States , Matthew Powell , Gynecologic Oncology , Washington University School ,