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A team of researchers has identified for the first time the neurons that are among the first victims of Alzheimer’s disease.

A major mystery in Alzheimer’s disease research is why some brain cells succumb to the creeping pathology of the disease years before symptoms first appear, while others seem impervious to the degeneration surrounding them until the disease’s final stages.   An image of human brain samples used to study why some brain cells are more vulnerable to Alzheimer’s disease than others. Image by Rana Eser, UCSF Grinberg lab Now, in a study published Jan. 10, 2021, in Nature Neuroscience, a team of molecular biologists and neuropathologists from the...

Studying brain tissue of 10 donors who had varying degrees of Alzheimer’s disease when they died, scientists discovered neurons in the parts of the brain that handle memory, navigation and self-awareness are early targets of the disease. PET scan of a human brain with Alzheimer’s disease. (Photo by US National Institute on Aging, Alzheimer’s Disease Education and Referral Center) (CN) — Different parts of the brain are more susceptible to the effects of Alzheimer’s disease than others, and according to a study released Monday the specific at-risk neurons have now been identified for...