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DGIST Ph.D. Candidate Receiving a Degree from DGIST and Maastricht University

DGIST Ph.D. Candidate Receiving a Degree from DGIST and Maastricht University
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Selective Vulnerability News: RORB Neurons Are First Victims of Tangles

21 Jan 2021
As Alzheimer’s tangle pathology progresses, neurodegeneration sweeps through the brain in a stereotypical fashion. But why do some neurons perish early on, while their neighbors persist until the bitter end? A study published January 11 in Nature Neuroscience addressed this question by tracing the gene-expression profiles of neurons in the brains of people who died in the early or late stages of the disease. Among myriad subpopulations of cells, the researchers zeroed in on subsets of excitatory neurons that express the transcription factor RORB as the first to succumb. Initially in the entorhinal cortex, and then later in the outer neocortex, excitatory neurons bearing this particular marker were selectively vulnerable to tau accumulation, and to death. The study, led by Lea Grinberg and Martin Kampmann, both at the University of California, San Francisco, also pegged a type of reactive astrocyte that may shirk its duties of protecting and nourishing neurons. In ....

United States , San Francisco , Martin Kampmann , Emmy Li , Matthew Huentelman , Jessica Rexach , Lea Grinberg , Los Angeles , Kun Leng , Jessica Shugart , Diego Mastroeni , Rick Livesey , Li Huei Tsai , Geidy Serrano , Hansruedi Mathys , Thomas Beach , Arizona State University In Tempe , University Of California , Massachusetts Institute Of Technology , Translational Genomics Research Institute , University College London Mathys , Nature Neuroscience , Massachusetts Institute , Orphan Receptor , University College London , Banner Sun Health Research Institute ,

Brain cells most vulnerable to Alzheimer's identified for first time

Brain cells most vulnerable to Alzheimer s identified for first time
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Scientists have identified the brain cells that are most vulnerable to Alzheimer s disease for the first time, in what s being referred to as the holy grail of dementia studies.
The brain cells lie in a region known as the entorhinal cortex, which controls memory, navigation and time perception, and are the first to be killed off by the disease.
The researchers hope the findings could be used to develop a new and much more targeted approach to developing therapies to slow or prevent the spread of Alzheimer s disease. ....

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Brain cells most vulnerable to Alzheimer's disease are identified by scientists for the first time

Scientists have identified the brain cells that are most vulnerable to Alzheimer s disease for the first time, in what s being referred to as the holy grail of dementia studies.
The brain cells lie in a region known as the entorhinal cortex, which controls memory, navigation and time perception, and are the first to be killed off by the disease.
The researchers hope the findings could be used to develop a new and much more targeted approach to developing therapies to slow or prevent the spread of Alzheimer s disease.
The brain cells lie in a region known as the entorhinal cortex, which controls memory, navigation and time perception, and are the first to be killed off by the disease ....

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Scientists Identify Brain Cells Most Vulnerable to Alzheimer's Disease

A team of researchers has identified for the first time the neurons that are among the first victims of Alzheimer’s disease. ....

Chan Zuckerberg Biohub , Salvatore Spina , Martin Kampmann , Lea Grinberg , Antonia Piergies , Carlosa Pasqualucci , Alexander Ehrenberg , Kun Leng , Emmi Li , Claudia Kimie Suemoto , Roberta Diehl Rodriguez , Williamw Seeley , Helmut Heinsen , Norma Neff , Renata Elaine Paraizo Leite , Department Of Neurology , Us National Institutes Of Health , Neurodegenerative Disease Brain Bank , University Of Wu , Tau Consortium , John Douglas French Alzheimer Foundation Endowed Professor , Institute For Neurodegenerative Diseases , Alzheimer Association , Weill Institute For Neurosciences , Nature Neuroscience , Neurodegenerative Diseases ,