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Phase 1 Data Support Further Investigation of RLY-4008 in FGFR2+ Cholangiocarcinoma

The FGFR2 inhibitor RLY-4008 generated early evidence of efficacy in patients with cholangiocarcinoma harboring FGFR2 fusions, according to findings from the phase 1/2 ReFocus trial, which were presented at the 2023 ASCO Annual Meeting. ....

United States , Futibatinib Lytgobi , Pemigatinib Pemazyre , Erdafitinib Balversa , Mayo Clinic Comprehensive Cancer Center , Taiho Pharmaceutical Co , Janssen Pharmaceutical Companies , Updated August , Updated September , Updated April , Novel Therapeutic Approaches To Target Fgfr2 Mutations In Cholangiocarcinoma ,

Erdafitinib improves outcomes vs. chemotherapy in advanced FGFR -altered urothelial cancer

CHICAGO — Erdafitinib improved OS, PFS and objective response rate compared with chemotherapy among patients with advanced or metastatic urothelial cancer with select fibroblast growth factor receptor alterations. Results of the phase 3 THOR trial, presented at ASCO Annual Meeting 2023, showed the FGFR inhibitor reduced the risk for death by 36% among the patient population compared with ....

United States , France General , Mindy Valcarcel , Danielp Petrylak , Bymatthew Shinkle , Immunomedics Incyte , Yohann Loriot , Gustave Roussy , Basilea Pharmaceutica , Astellas Pharma , Erdafitinib Balversa , Loxo Eli Lilly Co , Merck Kgaa , Gilead Sciences , Merck Kga , Nektar Therapeutics , Bristol Myers Squibb , Janssen Oncology , Eli Lilly ,