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Diagnostic Delays Drive Misdiagnoses in MS

A single-center, observational study conducted in the Czech Republic investigated the determining factors in delayed diagnoses in multiple sclerosis (MS) and how these delays impact patient outcomes. ....

Czech Republic , Tomas Uher , University Hospital , Charles University , Multiple Sclerosis , General University Hospital , Expanded Disability Status Scale , Diagnostic Delay ,

Tiziana Life Sciences Ltd.: Tiziana Life Sciences Doses First Patient in Phase 2a Trial of Intranasal Foralumab in Multiple Sclerosis

Tiziana Life Sciences Ltd.: Tiziana Life Sciences Doses First Patient in Phase 2a Trial of Intranasal Foralumab in Multiple Sclerosis
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Tanuja Chitnis , Paul Spencer , Stefan Klotter , Mattheww Davis , Irina Koffler , Gabriele Cerrone , Lifesci Advisors , Tiziana Life Sciences Ltd , Professor Of Neurology At Harvard Medical School , Business Development , Exchange Commission , Access Program , Tiziana Life Sciences , Expanded Disability Status Scale , Modified Fatigue Impact Scale , Principal Investigator , Mass General Brigham Healthcare System , Harvard Medical , Expanded Access Program , Chief Operating Officer , Chief Medical Officer , Life Sciences , Risk Factor , Annual Report , Exchange Commission The , Investor Relations ,

Tiziana Life Sciences Doses First Patient in Phase 2a Trial of Intranasal Foralumab in Multiple Sclerosis

19.12.2023 - NEW YORK, Dec. 19, 2023 (GLOBE NEWSWIRE) - Tiziana Life Sciences Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough neuro-immunomodulation therapies, today announced “first patient dosed” in its Phase . Seite 1 ....

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Significant Demographic and Clinical Differences Observed in Patterns Between NMOSD and MS

A recent meta-analysis revealed significant differences in characteristic between patients with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS), highlighting the need for enhanced tools to differentiate between these diseases for early and accurate diagnosis. ....

United States , United Kingdom , Saudi Arabia , City Of , Mohammed Alqwaifly , Qassim University , Unaizah College Of Medicine , Joanna Briggs Institute , Expanded Disability Status Scale , Patient With , New Africa , Unaizah College , Medical Sciences , Review Manager , Cochrane Collaboration , Latin America , Multiple Sclerosis , Neuromyelitis Optica Spectrum Disorder ,

Is vaccine response to SARS-CoV-2 preserved after switching to anti-CD20 therapies in patients with multiple sclerosis or related disorders?

Background Although vaccination against SARS-CoV-2 is recommended prior to introducing anti-CD20 therapies, limited data are available regarding the evolution of post-vaccinal immunity.

Methods This retrospective study compared anti-Spike antibody titres at 6 and 12 months from SARS-CoV-2 vaccination between patients vaccinated before switching to anti-CD20 (‘Switch’) and two control groups: (1) patients vaccinated under disease-modifying therapies (DMTs) other than fingolimod and anti-CD20 (‘Other DMTs’); (2) patients vaccinated on anti-CD20 (‘Anti-CD20’). Anti-Spike-specific T-cell responses were compared between ‘Switch’ and ‘Anti-CD20’ groups.

Results Fifty-three patients were included in the ‘Switch’ group, 54 in the ‘Other DMTs’ group and 141 in the ‘Anti-CD20’ group. At 6 months, in the subset of patients who received a booster dose, the ‘Switch’ group had lower anti-Spike titres compared with the ‘Other DMTs’ group (median 2 ....

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