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In vitro and in vivo Evaluation of the Bioactive Nanofibers-Encapsulated Benzalkonium Bromide for Accelerating Wound Repair with MRSA Skin Infection

* 1Department of Orthopeadics, The Affiliated Linfen Hospital of Shanxi Medical University, Linfen, Shanxi Province, People’s Republic of China; 2Department of Orthopeadics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, People’s Republic of China; 3Department of Orthopeadics, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong Province, People’s Republic of China *These authors contributed equally to this work Correspondence: Xinghua Song Department of Orthopeadics, The Affiliated Shunde Hospital of Jinan University, Foshan,...

P 0.05, vs PEEK). Discussion Because of outstanding biocompatibility and mechanical strengths, PEEK has been widely used as biomedical implants for replacing bone tissue, which is also a promising implantable material for dental applications. 27 However, because of bioinert and hydrophobicity, PEEK does not induce adhesion, proliferation, differentiation, mineralization of osteoblasts, or promote bone regeneration both in vitro and in vivo. 28 Bioactive-coated PEEK implants have become a promising bone replacement material, which combines the advantage of both bioactive coating and PEEK. 29 I...