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Molecular study reveals signs of inflammation in brains of people who died of COVID-19

Molecular study reveals signs of inflammation in brains of people who died of COVID-19
The most comprehensive molecular study to date of the brains of people who died of COVID-19 turned up unmistakable signs of inflammation and impaired brain circuits.
Investigators at the Stanford School of Medicine and Saarland University in Germany report that what they saw looks a lot like what s observed in the brains of people who died of neurodegenerative conditions such as Alzheimer s disease and Parkinson s disease.
The findings may help explain why many COVID-19 patients report neurological problems. These complaints increase with the severity of infection with SARS-CoV-2, the virus that causes COVID-19. And they can persist as an aspect of long COVID, a long-lasting disorder that sometimes arises following infection. About one-third of individuals hospitalized for COVID-19 report symptoms of fuzzy thinking, forgetfulness, difficulty concentrating and depression, said Tony ....

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Saarbrücken based bioinformaticians trace down molecular signals of Parkinson's disease

Credit: Oliver Dietze
In their study, which is now published in the journal
Nature Aging, they show that the level of non-coding RNAs in the blood of a Parkinson s patient can be used to track the course of the disease. For their study, the team led by bioinformatics professor Andreas Keller and his doctoral student Fabian Kern created and analyzed the molecular profiles of more than 5,000 blood samples from over 1,600 Parkinson s patients. This resulted in around 320 billion data points, which the researchers analyzed for biomarkers of Parkinson s disease using artificial intelligence methods. Our project is among the largest RNA biomarker studies in the world, says Andreas Keller, head of the research group for clinical bioinformatics at Saarland University and spokesperson for the Center for Bioinformatics at the Saarland Informatics Campus. ....

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Rare violin tests Germany's commitment to atone for its Nazi past

Rare violin tests Germany s commitment to atone for its Nazi past
Felix Hildesheimers music store in Speyer, Germany. The store occupied the first floor of the building, and the Hildesheimers lived on the floors above. Via David Sand via The New York Times.
by Catherine Hickley
(NYT NEWS SERVICE)
.- No one knows why Felix Hildesheimer, a Jewish dealer in music supplies, purchased a precious violin built by the Cremonese master Giuseppe Guarneri at a shop in Stuttgart, Germany, in January 1938. His own store had lost its non-Jewish customers because of Nazi boycotts, and his two daughters fled the country shortly afterward. His grandsons say its possible that Hildesheimer was hoping he could sell the violin in Australia, where he and his wife, Helene, planned to build a new life with their younger daughter. ....

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