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Women are at greater risk for dementia than men, probably because of waning estrogen levels following menopause. Estrogen is a key female hormone linked to reproductive, sexual, and neurological functions. A new study published in the journal Alzheimer's Research & Therapy examines how hormone replacement works in women with a high genetic risk for AD.

Hormone replacement therapy introduced early during the menopausal transition may protect against Alzheimer's dementia in women carrying the APOE4 gene, new research suggests.

Hormone replacement therapy (HRT) use was associated with better cognition, memory, and larger brain volume in women who carry the Alzheimer's associated APOE4 genetic variant.