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Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said. ....

United States , Gauri Kathote , Vikram Jakkamsetti , Qian Ma , Emily Henderson , Peiying Liu , Isaac Marin , Sharon Primeaux , Karthik Rajasekaran , Peter Odonnell Jr , Juan Pascual , Adrian Avila , Hanzhang Lu , Deepa Sirsi , Ut Southwestern Medical Center , Brain Institute , Eugene Mcdermott Center , Rare Brain Disorders Program , Science Translational Medicine , Human Growth , North America , Industry Focus , Isaac Marin Valencia , Sue Rose Distinguished Professorship , Once Upon , Time Foundation Professorship ,

UTSW scientists identify brain circuit that triggers rare, blood sugar-dependent epilepsy

Positron emission tomography (PET) images of mouse brains in the study show decreased brain glucose with GLUT1 (G1D) deficiency relative to normal (control). The color scale at right indicates the amount of glucose present, increasing up the scale. ....

United States , Gauri Kathote , Vikram Jakkamsetti , Qian Ma , Prasanna Alluri , Peiying Liu , Isaac Marin , Sharon Primeaux , Karthik Rajasekaran , Juan Pascual , Adrian Avila , Peter Odonnell Jr , Hanzhang Lu , Deepa Sirsi , Brain Institute , Eugene Mcdermott Center , Deficiency Foundation , National Institute Of Neurological Disorders , Rare Brain Disorders Program , Science Translational Medicine , Human Growth , North America , Isaac Marin Valencia , Sue Rose Distinguished Professorship , Once Upon , Time Foundation Professorship ,