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Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.
Credit: The Wistar Institute PHILADELPHIA -- (Jan. 21, 2021) -- Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Published in Cell, this study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers. EBV establishes life-long, latent infection in B lymphocytes, which can contribute to development of different cancer types, including Burkitt's lymphoma, nas...
Research finds new evidence about the mechanisms controlling skin repair and regeneration As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has found new evidence deep within the skin about the mechanisms controlling skin repair and renewal. Skin's barrier function gives it the unique ability to fight winter woes and retain water for our bodies. The outer layer of the skin, the epidermis, is constantly turning over to replace dead or damaged cells, creating new cells to reinforce the ...
Inflammation may contribute to the persistence of C. diff infection, shows study A new study from North Carolina State University shows that the inflammation caused by Clostridioides difficile ( C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive. C. diff is a bacterium that causes diarrhea, often with severe or even fatal consequences. As part of its growth cycle, C. diff produces two toxins that cause inflammation and damage the lining of the gut. " C. diff th...
Autopsies usually point to a cause of death but now a study of brain tissue collected from people who committed suicide may explain an underlying cause of major depression and suicide. The international research group, led by Dr. Michael O. Poulter of Robarts Research Institute at The University of Western Ontario and Dr. Hymie Anisman of the Neuroscience Research Institute at Carleton University, says that proteins that modify DNA directly are more highly expressed in the brains of people who commit suicide, they write in Biological Psychiatry. These proteins are involved in chemically modi...