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CRISPR genomic editing to obtain more productive and nutritive plant varieties

New study by the IBMCP of the UPV university facilitates the use of the CRISPR genomic editing technique on plants. ....

Francis Mojica , Emily Henderson , Polytechnic University Of Valencia , Institute Of Plant Molecular , Spanish National Research Council , Plant Molecular , Cellular Biology , Polytechnic University , Alicante Native Francis Mojica , Viral Vector , பிரான்சிஸ் மோஜிகா , எமிலி ஹென்டர்சன் , பாலிடெக்நிக் பல்கலைக்கழகம் ஆஃப் வலென்சியா , நிறுவனம் ஆஃப் ஆலை மூலக்கூறு , ஸ்பானிஷ் தேசிய ஆராய்ச்சி சபை , ஆலை மூலக்கூறு , செல்லுலார் உயிரியல் , பாலிடெக்நிக் பல்கலைக்கழகம் , அளிக்கண்டே பூர்வீகம் பிரான்சிஸ் மோஜிகா , வைரஸ் திசையன் ,

Study implicates disruption in prenatal neurogenesis in the development of ASDs

Study implicates disruption in prenatal neurogenesis in the development of ASDs
A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized progenitor cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs). The study also shows that estrogen, perhaps in a form produced within brain cells, can protect against this disruption and steer the brain on a normal course of development.
The most striking findings in the study, published on January 25, 2021 in
Neuron, were derived from experiments using embryos of the western clawed frog (Xenopus tropicalis), a species prized by biologists for the unique insights it offers into development. Human genes involved in development have counterparts with similar functions in Xenopus, and extensive studies correlating human embryonic stages with those of the frog mean that genetic studies in Xenopu ....

Jeremy Willsey , Helen Rankin Willsey , Richard Harland , Helen Willsey , Emily Henderson , Institute For Neurodegenerative Diseases , Behavioral Sciences , Department Of Psychiatry , Weill Institute For Neurosciences , Weill Institute , Oberndorf Family Distinguished Professor , Distinguished Professor , Neurodegenerative Diseases , Rankin Willsey , Developmental Biology , Mental Health , ரிச்சர்ட் ஹார்‌ல்யாஂட் , எமிலி ஹென்டர்சன் , நடத்தை அறிவியல் , துறை ஆஃப் மனநல மருத்துவம் , வெயில் நிறுவனம் க்கு நரம்பியல் , வெயில் நிறுவனம் , ஓபேர்ந்தோற்ப் குடும்பம் புகழ்பெற்ற ப்ரொஃபெஸர் , புகழ்பெற்ற ப்ரொஃபெஸர் , மன இறுக்கம் , வளர்ச்சி உயிரியல் ,

Gene screenings hold disease clues, but unexplained anomalies often raise fears

When her gynecologist recommended genetic testing, Mai Tran was reluctant. ....

United States , New York , Beverly Hills , Republic Of , Stanford University , Logan Marcus , Susan Domchek , Allison Kurian , Emily Henderson , Penn Medicine Abramson Cancer Center , Icahn School Of Medicine At Mount Sinai , American Society Of Clinical Oncology , Basser Center , New York City , Clinical Cancer Genetics Program , Meagan Farmer , Gene Counsel , Kenan Onel , Cancer Prevention , Icahn School , Mount Sinai , Clinical Oncology , Penn Medicine , Abramson Cancer , Breast Cancer , Health Care ,

Study identifies major flaws in iBMEC-based models of the blood-brain barrier

Study identifies major flaws in iBMEC-based models of the blood-brain barrier
A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.
The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the blood-brain barrier.
Many brain diseases, including brain cancers as well as degenerative and genetic disorders, could be much more treatable if researchers could get drugs across this barrier. For that and other reasons, iBMEC-based models of the barrier have been embraced as an important standard tool in brain research. ....

Tyler Lu , Ronaldo Perelman , David Redmond , Emily Henderson , Columbia University Irving Medical Center , Claudia Cohen Center , Research Specialist , Proceedings Of The National Academy Sciences , Ansary Stem Cell Institute , Memorial Sloan Kettering Cancer Center , Weill Cornell Medicine , Columbia University Irving Medical , Brain Microvascular Endothelial Cell , National Academy , Regenerative Medicine , Weill Cornell , Reproductive Medicine , Study First , Endothelial Cell , Gene Expression , Stem Cells , Transcription Factors , டைலர் லு , ரொனள்டோ பெரல்மேன் , டேவிட் ரெட்மண்ட் , எமிலி ஹென்டர்சன் ,

Inhibition of protein glycosylation successfully prevents SARS-CoV-2 infection in vitro

A new study provides direct evidence that the oligosaccharides attached to the viral surface spike protein are essential for viral infection, offering new approaches to preventive and therapeutic drugs. ....

Liji Thomas , Kateryna Kon Shutterstock , Kateryna Kon , Coronavirus Disease Covid 19 , In Vitro , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Cell Culture , Corona Virus , Protein Folding , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , Spike Protein , இல் விட்ரோ , செல் கலாச்சாரம் , கொரோனா வைரஸ் , சர்வதேச பரவல் , ப்ரோடீந் மடிப்பு , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி , ஸ்பைக் ப்ரோடீந் ,