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Study uncovers genetic similarities between PTSD and other mental health disorders

Study uncovers genetic similarities between PTSD and other mental health disorders
Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links. The challenge is further complicated by the wide range of symptoms exhibited by those who have PTSD. For instance, does extreme arousal, anger, or irritation experienced by some have the same genetic basis as the tendency to re-experience traumatic events, another symptom of the disorder?
A new study led by researchers at Yale and the University of California-San Diego (UCSD) provides answers to some of these questions and uncovers intriguing genetic similarities between PTSD and other mental health disorders such as anxiety, bipolar disorder, and schizophrenia. ....

United States , San Diego , Murray Stein , Joel Gelernter , Emily Henderson , Yale University , University Of California , Public Health , Million Veteran Program , Us Veterans Administration , Foundations Fund Professor Of Psychiatry , California San Diego , Foundations Fund Professor , Distinguished Professor , Bipolar Disorder , Post Traumatic Stress Disorder , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , முர்ரே ஸ்டீன் , எமிலி ஹென்டர்சன் , யேல் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பொது ஆரோக்கியம் , மில்லியன் மூத்த ப்ரோக்ர்யாம் , அடித்தளங்கள் நிதி ப்ரொஃபெஸர் ஆஃப் மனநல மருத்துவம் , கலிஃபோர்னியா சான் டியாகோ ,

Pharmacogenetic tests can benefit four million UK patients annually

Four million UK patients could benefit annually from genetic testing before being prescribed common medicines, according to new research from the University of East Anglia (UEA) in collaboration with Boots UK and Leiden University (Netherlands). ....

United Kingdom , Essra Youssef , Marc Donovan , Emily Henderson , Leiden University Netherlands , University Of East Anglia , School Of Pharmacy , East Anglia , Boots United Kingdom , Leiden University , Chief Pharmacist , Stomach Ulcer , ஒன்றுபட்டது கிஂக்டம் , எஸ்ரா யொஸ்செப் , மார்க் டொநொவந் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கிழக்கு ஆங்கிலியா , பள்ளி ஆஃப் மருந்தகம் , கிழக்கு ஆங்கிலியா , பூட்ஸ் ஒன்றுபட்டது கிஂக்டம் , தலைமை மருந்தாளர் , ஸ்டமக் புண் ,

New tool offers data-driven, precision medicine approach to help scientists better understand COVID-19

New tool offers data-driven, precision medicine approach to help scientists better understand COVID-19
It is called PAGER-CoV, and it promises to be an important tool in finding therapies for COVID-19. Simply put, PAGER-CoV is a database packed with nearly 12,000 (so far) pieces of genetic information on the SARS-CoV-2 virus, information that researchers and physicians can use to tailor treatments against the disease.
PAGER-CoV is an extension of PAGER, a database of gene sets created by Jake Chen, Ph.D., professor in the Department of Genetics at the University of Alabama at Birmingham and associate director of the Informatics Institute in the UAB School of Medicine. Chen created PAGER some 10 years ago while he was at Indiana University. As the pandemic spread in early 2020, Chen and his UAB colleagues created a similar system, PAGER-CoV, in response. ....

Jake Chen , Emily Henderson , Indiana University , School Of Medicine , Nucleic Acids Research , Informatics Institute , Department Of Genetics , University Of Alabama At Birmingham , Nucleic Acids , Genetic Information , Sars Cov 2 , ஜேக் சென் , எமிலி ஹென்டர்சன் , இந்தியானா பல்கலைக்கழகம் , பள்ளி ஆஃப் மருந்து , தகவல் நிறுவனம் , துறை ஆஃப் ஜெநெடிக்ஸ் , பல்கலைக்கழகம் ஆஃப் அலபாமா இல் பர்மிங்காம் , ஜெநெடிக் தகவல் , சர்வதேச பரவல் ,

Plants depend on LEAFY protein that enables cells to change their fate

Plants depend on LEAFY protein that enables cells to change their fate
Cells don t express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn t need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.
These unneeded genes are kept from becoming active by being stowed in dense chromatin, a tightly packed bundle of genetic material laced with proteins.
In a new study in the journal
Nature Communications, biologists from the University of Pennsylvania identified a protein that enables plant cells to reach these otherwise inaccessible genes in order to switch between different identities. ....

Doris Wagner , Kenneth Zaret , Emily Henderson , Nature Communications , School Of Arts Sciences , University Of Pennsylvania , Perelman School Of Medicine , Study Senior Author , Perelman School , Transcription Factors , டோரிஸ் வாக்னர் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , பள்ளி ஆஃப் கலைகள் அறிவியல் , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , பெரல்மேன் பள்ளி ஆஃப் மருந்து , படிப்பு மூத்தவர் நூலாசிரியர் , பெரல்மேன் பள்ளி , படியெடுத்தல் காரணிகள் ,

Innovative breakthrough promises to diagnose DNA rearrangement mutations

Innovative breakthrough promises to diagnose DNA rearrangement mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.
However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in the lengths of genes in a DNA sequence. These variations in gene length, known as polymorphisms, can be key to accurately diagnosing many forms of c ....

United States , Alden Chesney , Jason Reed , Amir Toor , Emily Henderson , School Of Medicine , College Of Humanities , Virginia Commonwealth University Massey Cancer Center , American Society Of Hematology , Department Of Pathology , Association Of Molecular Pathology , Professor In Department Of Physics , Department Of Physics , Member Of Cancer Biology Research Program , Massey Cancer Center , Molecular Pathology , American Society , Cancer Center , Cancer Biology Research Program , Associate Professor , Virginia Commonwealth , Developmental Therapeutics , Dna Sequencing , Atomic Force Microscopy , Polymerase Chain Reaction , ஒன்றுபட்டது மாநிலங்களில் ,