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Study provides a detailed look at vulnerable sites on SARS-CoV-2

Study provides a detailed look at vulnerable sites on SARS-CoV-2
A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus beyond the key sites on the virus s spike protein. By attacking the virus from many angles, the body has the tools to potentially recognize different SARS-CoV-2 variants.
The new research, published January 27, 2021 in
Cell Report Medicine, is the most detailed analysis so far of which proteins on SARS-CoV-2 stimulate the strongest responses from the immune system s helper CD4+ T cells and killer CD8+ T cells. ....

United Kingdom , United States , San Diego , Alba Grifoni , Alessandro Sette , Emily Henderson , University Of California , Australia Murdoch University , Jolla Institute For Immunology , Coronavirus Task , Cell Report Medicine , Task Force , Sars Cov 2 , Immune Response , Immune System , Spike Protein , ஒன்றுபட்டது கிஂக்டம் , ஒன்றுபட்டது மாநிலங்களில் , சான் டியாகோ , Alessandro செத்தே , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , ஆஸ்திரேலியா முர்டோக் பல்கலைக்கழகம் , ஜொல்லா நிறுவனம் க்கு நோயெதிர்ப்பு , செல் அறிக்கை மருந்து , பணி படை ,

New results challenge the current understanding of medulloblastoma

New results challenge the current understanding of medulloblastoma
Scientists at St. Jude Children s Research Hospital and their colleagues have published a detailed account of SJMB03, a clinical trial for pediatric patients with medulloblastoma.
Additionally, they report results of the largest analysis of matched primary and relapsed medulloblastoma tumors to date. In both the clinic and the lab, results underscore the need for integrated molecular assessment of these tumors. The papers were published recently in the
Journal of Clinical Oncology.
Clinical trial confirms subgroups, highlights need for additional analysis
Medulloblastoma is among the most common malignant pediatric brain tumors. Previous research by St. Jude scientists and others has classified medulloblastoma into four distinct molecular groups: WNT and SHH (which are driven by their namesake genetic mutations), Group 3, and Group 4. ....

Amar Gajjar , Paul Northcott , Giles Robinson , Emily Henderson , Jude Department Of Pediatric Medicine , Jude Children Research Hospital , Jude Children , Research Hospital , Jude Department , Study Corresponding Author , Jude Developmental Neurobiology , Clinical Trial , அமர் கஜ்ஜார் , பால் நார்த்காட் , கில்ஸ் ராபின்சன் , எமிலி ஹென்டர்சன் , ஜூட் துறை ஆஃப் குழந்தை மருந்து , ஜூட் குழந்தைகள் ஆராய்ச்சி மருத்துவமனை , ஜூட் குழந்தைகள் , ஆராய்ச்சி மருத்துவமனை , ஜூட் துறை , ஜூட் வளர்ச்சி நரம்பியல் , மருத்துவ சோதனை ,

Genetic changes in tumors can help predict the efficacy of immunotherapy drugs

Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumors which could be used to predict if immunotherapy drugs would be effective in individual patients. ....

United Kingdom , Kevin Litchfield , Charles Swanton , Michelle Mitchell , Emily Henderson , Cancer Research , Cancer Research United Kingdom , Cancer Institute , Francis Crick Institute , Tumour Immunogenomics , Chief Executive , Francis Crick , Gene Expression , Immune Response , Lung Cancer , Medical Research , ஒன்றுபட்டது கிஂக்டம் , கெவின் லிட்ச்பீல்ட் , சார்லஸ் ஸ்வாண்டன் , மைக்கேல் மிட்செல் , எமிலி ஹென்டர்சன் , புற்றுநோய் ஆராய்ச்சி , புற்றுநோய் ஆராய்ச்சி ஒன்றுபட்டது கிஂக்டம் , புற்றுநோய் நிறுவனம் , பிரான்சிஸ் கிரிக் நிறுவனம் , தலைமை நிர்வாகி ,

Viral ExoN regulates the rate of recombination in SARS-CoV-2

Viral ExoN regulates the rate of recombination in SARS-CoV-2
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
The coronavirus is an RNA virus that has, in its enzymatic toolkit, a proofreading exoribonuclease, called nsp14-ExoN, which can correct errors in the RNA sequence that occur during replication, when copies of the virus are generated.
Using cutting-edge technologies and novel bioinformatics approaches, the researchers discovered that this ExoN also regulates the rate of recombination, the ability of the coronavirus to shuffle parts of its genome and even pull in genetic material from other viral strains while it replicates in order to gain evolutionary advantage. ....

Mark Denison , James Chappell , Andrea Pruijssers , Maria Agostini , Jennifer Gribble , Emily Henderson , Xiaotao Lu , Edward Claiborne Stahlman , Laura Stevens , Andrew Routh , Vanderbilt University Medical Center , Researchers At Vanderbilt University Medical Center , Study Co , Vanderbilt University School Of Medicine , University Of Texas Medical Branch , Division Of Pediatric Infectious Diseases , Texas Medical Branch , Middle Eastern , Molecular Biology , Pediatric Infectious Diseases , Jordan Anderson Daniels , Edward Claiborne Stahlman Chair , Pediatric Physiology , Cell Metabolism , Vanderbilt University School , Study Co Corresponding Author ,

Researchers develop new computational method for studying genetic and environmental interactions

Researchers develop new computational method for studying genetic and environmental interactions
Researchers at Weill Cornell Medicine and Cornell University s Ithaca campus have developed a new computational method for studying genetic and environmental interactions and how they influence disease risk.
The research, published Jan. 7 in
The American Journal of Human Genetics, makes the process of finding these interactions much less difficult and demonstrates their importance in determining body mass index and diabetes risk.
Our study demonstrates that your genes matter and the environment matters and that the interaction of the two can increase risk for disease, said co-senior author, Dr. Olivier Elemento, who is professor of computational genomics in computational biomedicine, professor of physiology and biophysics, associate director of the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, and director of the Caryl an ....

New York , United States , Cornell University , Andrew Clark , Jacob Gould Schurman , Olivier Elemento , Emily Henderson , Andrew Marderstein , Department Of Molecular Biology , College Of Arts Sciences , Cornell University Ithaca , Peter Meinig Family Investigator At Cornell University , Weill Cornell Graduate School Of Medical Sciences , School Of Medical Sciences , Weill Cornell Medicine , American Journal , Human Genetics , Computational Biomedicine , Israel Englander Institute , Precision Medicine , Weill Cornell , Weill Cornell Graduate School , Medical Sciences , New York City , Jacob Gould Schurman Professor , Population Genetics ,