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NIH awards $5.59 million research grants to prevent and treat cerebral palsy

NIH awards $5.59 million research grants to prevent and treat cerebral palsy
The National Institutes of Health is supporting a Wayne State University School of Medicine physician-researcher s work at preventing and treating cerebral palsy in the form of two new five-year R01 grants worth a collective $5.59 million.
The principal investigator on both projects is Sidhartha Tan, M.D., professor and co-division chief of Neonatology in the Department of Pediatrics.
Cerebral palsy is a group of disorders that affect a person s ability to move and maintain balance and posture. CP is the most common motor disability in childhood, caused by abnormal brain development or damage to the developing brain that affects a person s ability to control his or her muscles. ....

Wayne State University School Of Medicine , United States , Wayne State University , Jie Xu , Jeannette Vasquez Vivar , Emily Henderson , National Institutes Of Health , Department Of Pediatrics , College Of Wisconsin , University Of Michigan , National Institutes , Wayne State University School , Sidhartha Tan , Neuronal Nitric Oxide Synthase Inhibition , Cerebral Palsy , Principal Investigator , Co Division Chief , Wayne State , Using Transgenic Rabbits , Medical College , Animal Model , Nitric Oxide , வேன் நிலை பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஒன்றுபட்டது மாநிலங்களில் , வேன் நிலை பல்கலைக்கழகம் , ஜிே ஐயூ ,

New data shows that mINDY gene is involved in blood pressure regulation

New data shows that mINDY gene is involved in blood pressure regulation
Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the
Journal of Clinical Investigation (JCI) insight.
Reduced expression of mINDY, which is known to extend the life span in lower organisms and to prevent diet induced obesity, fatty liver, and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents.
The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knockout model as well as microarray and in vitro studies. ....

Andreas Birkenfeld , Emily Henderson , Diabetes Research , German Center , Clinical Investigation , Blood Pressure , Fatty Liver , Heart Rate , In Vitro , In Vivo , Insulin Resistance , ஆண்ட்ரியாஸ் பிர்கன்பெல்ட் , எமிலி ஹென்டர்சன் , நீரிழிவு நோய் ஆராய்ச்சி , ஜெர்மன் மையம் , மருத்துவ விசாரணை , இரத்தம் ப்ரெஶர் , நீரிழிவு நோய் , கொழுப்பு கல்லீரல் , இதயம் ரேட் , இல் விட்ரோ , இல் விவோ , இன்சுலின் எதிர்ப்பு , உடல் பருமன் ,

Hybrid closed-loop insulin therapy improves glycemic control in adolescents, young adults

Hybrid closed-loop insulin therapy improves glycemic control in adolescents, young adults
Hybrid closed-loop insulin therapy improved glycemic control in adolescents and young adults with type 1 diabetes. These outcomes, derived from the International Diabetes Closed-Loop (iDCL) Trial, are reported in the peer-reviewed journal
Diabetes Technology & Therapeutics (DTT).
Adolescents and young adults with a mean age of 17 years were randomly assigned to a closed-loop control (CLC) insulin delivery system or a sensor augmented pump (SAP) with a continuous glucose monitoring system over a 6-month period. The Time in Range increased by 13% for the CLC group, compared to a decrease of 1% with SAP, for a group difference of +3.1 hours/day. This reflected a reduction in time spent at >180 mg/dL. The use of CLC was especially effective at increasing Time in Range overnight. ....

United States , John Lum , Satish Garg , Emily Henderson , Diabetes Technology Therapeutics , Jaeb Center , International Diabetes , University Of Colorado , Dcl Trial Research Group , Health Research , International Diabetes Closed Loop , Diabetes Technology , Automated Insulin Delivery , Genetic Engineering , Type 1 Diabetes , ஒன்றுபட்டது மாநிலங்களில் , ஜான் லம் , சத்தீஷ் கார்க் , எமிலி ஹென்டர்சன் , நீரிழிவு நோய் தொழில்நுட்பம் சிகிச்சை , சர்வதேச நீரிழிவு நோய் , பல்கலைக்கழகம் ஆஃப் கொலராடோ , திகில் சோதனை ஆராய்ச்சி குழு , ஆரோக்கியம் ஆராய்ச்சி , சர்வதேச நீரிழிவு நோய் மூடப்பட்டது வளைய , நீரிழிவு நோய் தொழில்நுட்பம் ,

Genetic interactions may shed light on NGLY1 deficiency

Genetic interactions may shed light on NGLY1 deficiency
In 2012, four-year-old Bertrand Might became the first-ever patient diagnosed with a rare genetic disorder called N-glycanase (NGLY1) deficiency. The discovery of this condition and Bertrand s diagnosis allowed doctors to look for other children with the same genetic defect. Since then, more than 60 additional patients have been found.
The disease affects every system of the body and is characterized by low muscle tone, seizures, developmental delays, and an inability to produce tears.
Sadly, Bertrand passed away in October at the age of 12. Although his life was cut short, his legacy will benefit children around the world. Through their website, NGLY1.org, Bertrand s parents collect and share a wealth of research and family stories to help educate and inform the community. As more patients have been identified, it s become apparent that even though the same gene is deactivated in all of them, their symptoms and s ....

Clement Chow , Emily Henderson , University Of Utah Health , Drosophila Genetic Reference Panel , Department Of Human Genetics , Bertrand Might , Human Genetics , Utah Health , Drosophila Genetic Reference , Assistant Professor , Genetic Disorder , Ngly1 Deficiency , கிளெமென்ட் சோவ் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் உட்டா ஆரோக்கியம் , துறை ஆஃப் மனிதன் ஜெநெடிக்ஸ் , பெர்ட்ராண்ட் வலிமை , மனிதன் ஜெநெடிக்ஸ் , உட்டா ஆரோக்கியம் , உதவியாளர் ப்ரொஃபெஸர் , ஜெநெடிக் கோளாறு ,

Green River Killer Gary Ridgway's youngest victim identified

Wendy Stephens was 14 years old when she ran away in 1983. ....

United States , Wendy Stephens , Tim Meyer , Dan Satterberg , Gary Ridgway , Wendy Stephen , Cheryl Wims , King County Sheriff Office , Green River Killer , King County Sheriff , County Prosecutor Dan Satterberg , Washington State , ஒன்றுபட்டது மாநிலங்களில் , வெண்டி ஸ்டீபன்ஸ் , நேரம் மேயர் , கேரி ரிட்வே , வெண்டி ஸ்டீபன் , செரில் விம்ஸ் , கிங் கவுண்டி ஷெரிப் அலுவலகம் , பச்சை நதி கில்லர் , கிங் கவுண்டி ஷெரிப் , வாஷிங்டன் நிலை ,